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Manufactured by BioVendor

CCL7 (MCP-3) (Biotinylated) Human E.coli

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:E. coli
  • Other names:MCP-3, C-C motif chemokine 7, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3,MCP-3, NC28, Small-inducible cytokine A7, CCL7, MCP3, SCYA6, SCYA7
  • Species:Human
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Cat. No. Size Price


RD172387002-BIOTIN 0.002 mg
RD172387010-BIOTIN 0.01 mg
RD172387050-BIOTIN 0.05 mg
PubMed Product Details
Technical Data

Type

Recombinant protein

Description

Total 95 AA. MW: 11,2 kDa (calculated). Biotinylated at the last Lysine in sequence. UniProtKB acc.no# P80098 (24–99) Protein identity confirmed by LC-MS/MS.

Amino Acid Sequence

QPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWVQDFMKHLDKKTQTPKLKLGSGLNDIFEAQKIEWHE

Source

E. coli

Purity

> 97% by SDS PAGE

Biological Activity

EC50 = 1.4–2.6 nM determined by migration assay with cells expressing recombinant CCR2

Endotoxin

<0.01 EU per 1µg of the protein

Reconstitution

Add sterile water to prepare a working stock solution of approximately 0.1 mg/ml and let the lyophilized pellet dissolve completely.

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the lyophilized protein at –20 to –70 °C. Lyophilized protein remains stable until the expiry date when stored at-20 to –70 °C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -20 to –70 °C, the protein is stable for 3 months at –20 to –70 °C under sterile conditions after reconstitution. Reconstituted protein can be stored at 4 °C for 1 month under sterile conditions after reconstitution

Quality Control Test

Quantification is done by A280, using the calculated extinction coefficient (14,180 M-1 cm-1).
SDS-PAGE to determine purity of the protein.
LAL TEST to determine endotoxin level.

Note

This product is intended for research use only.

Summary

Research topic

Chemokines, Cytokines and chemokines and related molecules

Summary

Monocyte chemotactic protein 3 (MCP3)(CCL7) is secreted by monocytes and certain tumer cell lines. It is a chemoattractant for monocytes and other leukocytes. MCP3 binds and signals through several cell surface receptors including CCR1, CCR2, CCR3, and appears to be an antagonist for CCR5.

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