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Manufactured by BioVendor

CDNF Human E. coli

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:E. coli
  • Other names:ARMET-Like Protein 1, ARMETL1, Conserved Dopamine Neurotrophic Factor, Cerebral Dopamine Neurotrophic Factor
  • Species:Human
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Cat. No. Size Price

RBG10103005 5 µg
RBG10103025 25 µg
RBG10103100 100 μg
PubMed Product Details
Technical Data


Recombinant protein


CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease.

Amino Acid Sequence



E. coli



Biological Activity

Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15–25 µg/ml.


Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).


Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1–1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at –20°C to –80°C




Research topic

Neural tissue markers

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