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Chitinase 3-Like 1 Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:CHI3L1, YKL-40
  • Species:Human
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Cat. No. Size Price


RD193444200CS 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Plasma (EDTA, citrate, heparin)

Sample Requirements

5 µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box)

Calibration Curve

Calibration Range

0.125–4 ng/ml

Summary

Features

  • It is intended for research use only
  • The total assay time is less than 5 hours
  • The kit measures CHI3L1 in human serum and plasma (EDTA, citrate, heparin)
  • Assay format is 96 wells
  • Standard is a recombinant protein produced in NSO cells
  • Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Immune Response, Infection and Inflammation

Summary

Chitinase 3-like 1 (CHI3L1), also called cartilage glycoprotein 39 or YKL-40 in human and breast regression protein 39 in mice, is a 40 kDa chitin-binding glycoprotein without chitinase activity, and it has been shown to act as an important regulator of acute and chronic inflammation.
This molecule is synthesized under inflammatory conditions, including bronchial asthma, inflammatory bowel disease, and cancer, but is not highly expressed under physiological conditions. This glycoprotein is expressed and secreted by a variety of cell types including articular chondrocytes, synoviocytes, osteoblasts, macrophages, neutrophils, and epithelial cells.
Up to now, several studies have shown an important link between CHI3L1 and inflammation or metabolic diseases, including asthma, hypertension, diabetes mellitus, insulin resistance, and atherosclerosis, and naturally believe that CHI3L1 may be a potential biomarker and therapeutic target for the related diseases.
It is also highly regulated, being stimulated by a number of mediators including IL-13 and IFN-γ and being detected in exaggerated quantities in the circulation and or biologic fluids from patients with a spectrum of diseases including asthma, COPD, rheumatoid arthritis, cancer, diabetes, and atherosclerosis. YKL-40/Chi3l1 is elevated in the serum of patients with community-acquired pneumonia requiring hospitalizations, patients with cystic fibrosis and acute lung infections, and control subjects following endotoxin injection.

References to Summary

References to Chitinase 3-Like 1

  • Dela Cruz CS, Liu W, He CH, Jacoby A, Gornitzky A, Ma B, Flavell R, Lee CG, Elias JA. Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses. Cell Host Microbe. 2012 Jul 19;12 (1):34-46
  • Gong Z, Xing S, Zheng F, Xing Q. Increased expression of chitinase 3-like 1 in aorta of patients with atherosclerosis and suppression of atherosclerosis in apolipoprotein E-knockout mice by chitinase 3-like 1 gene silencing. Mediators Inflamm. 2014;2014:905463
  • Libreros S, Garcia-Areas R, Keating P, Carrio R, Iragavarapu-Charyulu VL. Exploring the role of CHI3L1 in "pre-metastatic" lungs of mammary tumor-bearing mice. Front Physiol. 2013;4:392
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