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Cortisone Chemiluminescent StressXpress® Immunoassay Kit

  • Regulatory status:RUO
  • Type:Competitive CLIA
  • Species:Multispecies
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Cat. No. Size Price


RSKT-206R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Competitive CLIA

Applications

Serum, Urine, Saliva

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

78.1–20,000 pg/ml

Limit of Detection

59.6 pg/mL

Summary

Features

  • CLIA kit used to quantitate cortisone concentration in samples
  • The total assay time is less than 2,5 hours

Research topic

Others, Steroid hormones

Summary

Cortisone, a steroid hormone, is released by the adrenal gland during times of stress. It is the less active form of Cortisol. The β-hydroxysteroid dehydrogenases (11-HSD) are a pair of enzymes with the ability to convert cortisone to cortisol (11-HSD1) or deactivate cortisol by converting it to cortisone (11-HSD2). This glucocorticoid conversion event helps to initiate and regulate the anti-inflammatory response. Monitoring the ratio of cortisone:cortisol has applications in diabetes, obesity, metabolic syndrome, osteoporosis, and chronic fatigue syndrome in addition to adrenal diseases.

References to Summary

References to Cortisone

  • Hadoke PW, Iqbal J, Walker BR. Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease. Br J Pharmacol. 2009 Mar;156 (5):689-712
  • Hillier SG. Diamonds are forever: the cortisone legacy. J Endocrinol. 2007 Oct;195 (1):1-6
  • Jerjes WK, Peters TJ, Taylor NF, Wood PJ, Wessely S, Cleare AJ. Diurnal excretion of urinary cortisol, cortisone, and cortisol metabolites in chronic fatigue syndrome. J Psychosom Res. 2006 Feb;60 (2):145-53
  • Pierotti S, Gandini L, Lenzi A, Isidori AM. Pre-receptorial regulation of steroid hormones in bone cells: insights on glucocorticoid-induced osteoporosis. J Steroid Biochem Mol Biol. 2008 Feb;108 (3-5):292-9
  • van Raalte DH, Ouwens DM, Diamant M. Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options?. Eur J Clin Invest. 2009 Feb;39 (2):81-93
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