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Distributed product

Cyclic AMP High-Sensitivity Direct Chemiluminescent StressXpress® Immunoassay Kit

  • Regulatory status:RUO
  • Type:Competitive CLIA
  • Species:Multispecies
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Cat. No. Size Price


RSKT-208R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Competitive CLIA

Applications

Plasma-EDTA, Plasma-Heparin, Urine, Cell lysate, Saliva, Tissue culture medium

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

0.039–5 pmol/ml

Limit of Detection

0.076 pmol/mL

Summary

Features

  • CLIA kit used to quantitate cAMP in cell lysates, plasma, urine, saliva, tissue and culture media samples
  • The total assay time is less than 2,5 hours

Research topic

Others

Summary

Adenosine-3’,5’-cyclic monophosphate (cyclic AMP) is a second messenger that plays an important role in intracellular regulation. Specifically, it functions as a mediator of activity of several key hormones. The activity of cAMP has implications in innate immune functioning, inflammation, axon regeneration and cancer.

References to Summary

References to Cyclic AMP

  • Galea E, Feinstein DL. Regulation of the expression of the inflammatory nitric oxide synthase (NOS2) by cyclic AMP. FASEB J. 1999 Dec;13 (15):2125-37
  • Hannila SS, Filbin MT. The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury. Exp Neurol. 2008 Feb;209 (2):321-32
  • Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M. Cyclic AMP: master regulator of innate immune cell function. Am J Respir Cell Mol Biol. 2008 Aug;39 (2):127-32
  • Shankar DB, Cheng JC, Sakamoto KM. Role of cyclic AMP response element binding protein in human leukemias. Cancer. 2005 Nov 1;104 (9):1819-24
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