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Estriol free in saliva ELISA

  • Regulatory status:RUO
  • Type:Competitive ELISA
  • Other names:E3
  • Species:Multispecies
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Cat. No. Size Price


RTC014R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Competitive ELISA

Applications

Saliva

Sample Requirements

50 µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

2.5 – 4000 pg/ml

Limit of Detection

1.4 pg/ml

Summary

Features

Incubation time: 60 min, 30 min at RT

Research topic

Steroid hormones

Summary

Estriol (E3) is the major estrogen formed by the fetoplacental unit during pregnancy. Unconjugated E3 passes through the placenta into the maternal circulation, where it is rapidly converted into glucuronide and sulfate derivatives to facilitate its excretion. The half-life of estriol in the maternal bloodstream is only 20–30 minutes. Its measurement, therefore offers a convenient and quick evaluation of current fetal status. Plasma estriol levels increase steadily throughout pregnancy and most rapidly during the third trimester (28–40 weeks). A sudden decrease in fetoplacental E3 production will result in a rapid fall in unconjugated E3 in the maternal serum. There are several potential advantages to measuring unconjugated E3 rather than total serum or urinary E3. Unconjugated estriol levels are free from effects related to maternal renal or hepatic disease, and are not altered by the administration of certain antibiotics. Unconjugated E3 more accurately reflects fetal outcome in diabetic pregnancies – and since no hydrolysis of unconjugated E3 is required, a more rapid turnaround for the test result is possible.

References to Summary

References to Estriol

  • Bashore RA, Westlake JR. Plasma unconjugated estriol values in high-risk pregnancy. Am J Obstet Gynecol. 1977 Jun 15;128 (4):371-80
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