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Fibronectin Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:Cold insoluble globulin, FINC, LETS, MSF, FN
  • Species:Human
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Cat. No. Size Price


RD191403200CS 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Plasma (EDTA, citrate, heparin)

Sample Requirements

5 µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box)

Calibration Range

1–50 ng/ml

Summary

Features

  • It is intended for research use only
  • The total assay time is less than 3 hours
  • The kit measures fibronectin in human serum and plasma (EDTA, citrate, heparin)
  • Assay format is 96 wells
  • Standard is a native protein purified from human plasma
  • Components of the kit are provided ready to use, concentrated or lyophilized

**Clinical use and areas of investigation: **

  • Kidney cancer

Research topic

Oncology, Transplantation

Summary

Fibronectin is an ubiquitous extracellular glycoprotein that exists in a soluble form in body fluids
and in an insoluble form in the extracellular matrix. It plays a major role in many important
physiological processes, such as embryogenesis, wound healing, hemostasis and thrombosis.
Fibronectin is secreted as a dimer with a monomer molecular weight of 220-250 kDa. Fibronectin is composed of three types of modules organized into functional domains that are
resistant to proteolysis and contain binding sites for extracellular matrix proteins, cell surface
receptors and circulating blood proteins.
In general, fibronectin is synthesized by and present around fibroblasts, endothelial cells,
chondrocytes, glial cells, and myocytes. Fibronectin is abundant in the connective tissue matrix
and in basement membranes. Extremely high levels of the glycoprotein are found in plasma.
Fibronectin has been reported to play a major role in the cardiovascular system, being
functionally involved in blood clotting, atherosclerosis, hypertension and myocardial infarction.
Fibronectin´s importance during cancer progression has further been shown. It represents an
active element in the process of T cell activation in the immune cascade triggered by organ
transplantation. Fetal fibronectin has been described as a predictor of term labor.

Clinical use and areas of investigation:

  • Kidney cancer
References to Summary

References to Fibronectin

  • Johansson S, Svineng G, Wennerberg K, Armulik A, Lohikangas L. Fibronectin-integrin interactions. Front Biosci. 1997 Mar 1;2:d126-46
  • Sabatino M, Kim-Schulze S, Panelli MC, Stroncek D, Wang E, Taback B, Kim DW, Deraffele G, Pos Z, Marincola FM, Kaufman HL. Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy. J Clin Oncol. 2009 Jun 1;27 (16):2645-52
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