Select country change
Shopping cart (0 , 0,00 ) Menu Search
Manufactured by BioVendor

Galectin-1 Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:Beta-galactoside-binding lectin L-14-I, Galaptin, 14 kDa lectin, S-LAC lectin-1
  • Species:Human
Please select your region to see available products and prices.
Cat. No. Size Price


RD191437200CS 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Plasma (EDTA, citrate, heparin)

Sample Requirements

35 µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box)

Calibration Curve

Calibration Range

0.25–8 ng/ml

Summary

Features

  • It is intended for research use only
  • The total assay time is less than hours
  • The kit measures GAL-1 in human serum and plasma (EDTA, citrate, heparin)
  • Assay format is 96 wells
  • Standard is a recombinant protein produced in E.coli
  • Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Apoptosis, Immune Response, Infection and Inflammation, Oncology

Summary

Galectins are proteins of 30 kDa that can be found in the cellular nucleus, the cytosol and also in the extracellular space. They are members of the lectin family, a group of β-galactoside binding proteins. Galectin-1 [GAL-1] is a prototypical member of the galectin family of lectins. It is a divalent 14.5-kDa protein characterized by one carbohydrate recognition domain (CRD) that can occur as a monomer or as a non-covalent homodimer consisting of subunits of one CRD. GAL-1 is produced by a variety of vascular, interstitial, epithelial, and immune cells. GAL-1 is present both inside and outside cells, and has both intracellular and extracellular functions. The extracellular functions require the carbohydratebinding properties while the intracellular ones are associated with protein-protein interactions. Galectin-1, a member of carbohydrate-binding proteins with an affinity for b-galactoside, was found strong expressed in the isolated activated PSCs. Galectin-1 is widely distributed in many normal and pathological tissues and appears to be functionally polyvalent, such as regulating cell proliferation, differentiation and apoptosis, mediating tumor transformation, growth and so on. It is widely reported that Galectin-1 is overexpressed in many different types of digestive systém tumors, including gastric cancer, colorectal cancer and hepatocellular carcinoma.

References to Summary

References to Galectin-1

  • Al-Salam S, Hashmi S. Galectin-1 in early acute myocardial infarction. PLoS One. 2014;9 (1):e86994
  • Tang D, Zhang J, Yuan Z, Gao J, Wang S, Ye N, Li P, Gao S, Miao Y, Wang D, Jiang K. Pancreatic satellite cells derived galectin-1 increase the progression and less survival of pancreatic ductal adenocarcinoma. PLoS One. 2014;9 (3):e90476
  • von Klot CA, Kramer MW, Peters I, Hennenlotter J, Abbas M, Scherer R, Herrmann TR, Stenzl A, Kuczyk MA, Serth J, Merseburger AS. Galectin-1 and Galectin-3 mRNA expression in renal cell carcinoma. BMC Clin Pathol. 2014;14:15
Related Products Documents