Exact inter-species homology was found for example for:
Bornean orangutan Brown anole Brown bat Carolina anole Catfish Chimpanzee Cow Crossostoma Dog Goat
Horse King cobra Mouse Rat Salmon Short-tailed opossum Western gorilla Wild boar Xenopus
It is intended for research use only
The total assay time is less than 2.5 hours
The kit measures hsa-miR-145-5p isolated from human blood
Assay format is 96 wells
Standard is synthetic miRNA-based
Components of the kit are provided ready to use, concentrated or dried
Cardiovascular disease, Oncology
MicroRNAs (miRNAs) are small non-coding RNA molecules, approximately 22
nucleotides in length that regulate gene translation through silencing or degradation
of target mRNAs. They are involved in multiple biological processes, including
differentiation and proliferation, metabolism, hemostasis, apoptosis or inflammation,
and in pathophysiology of many diseases. Numerous studies have suggested
circulating miRNAs as promising diagnostic and prognostic biomarkers of many
miR-145-5p is considered a member of the p53-tumor suppressor network and has
been found to act as a post-transcriptional regulator of many cancer-related genes.
Deregulations of miR-145-5p were observed in various types of human cancer
including renal cancer, colorectal cancer, bladder cancer, lung cancer, glioblastoma
and prostate cancer.
miR-145-5p is also involved in pathology of cardiovascular disease. miR-145-5p
plasma levels were reported to be significantly lower in patients with acute
myocardial infarction compared to healthy control group. Increased plasma levels
of miR-145-5p were found in population with genetic predisposition to familiar dilated
miR-145-5p is associated also with cerebral ischemia, where expression was
significally higher in ischemic stroke patients when compare to control subjects.
Summary References (9)
References to miR-145-5p
Papadopoulos, Emmanuel I., et al. "Clinical evaluation of microRNA-145
expression in renal cell carcinoma: a promising molecular marker for
discriminating and staging the clear cell histological subtype." Biological
chemistry 397.6 (2016): 529-539.
Li, Jialu, et al. "Serum miRNA expression profile as a prognostic biomarker of
stage II/III colorectal adenocarcinoma." Scientific reports 5 (2015): 12921.
Inamoto, Teruo, et al. "A Panel of MicroRNA Signature as a Tool for Predicting
Survival of Patients with Urothelial Carcinoma of the Bladder." Disease Markers
Zhang, Hui, et al. "Plasma miR-145, miR-20a, miR-21 and miR-223 as novel
biomarkers for screening early-stage non-small cell lung cancer." Oncology
letters 13.2 (2017): 669-676.
Zhao, Hua, et al. "Serum microRNA profiling in patients with glioblastoma: a
survival analysis." Molecular cancer 16.1 (2017): 59.
Goto, Yusuke, et al. "Impact of novel miR-145-3p regulatory networks on
survival in patients with castration-resistant prostate cancer." British journal of
cancer 117.3 (2017): 409.
Zhang, Ming, et al. "Circulating MicroRNA-145 is associated with acute
myocardial infarction and heart failure." Chinese medical journal 130.1 (2017): 51.
Toro, Rocío, et al. "Plasma microRNAs as biomarkers for Lamin A/C-related
dilated cardiomyopathy." Journal of Molecular Medicine 96.8 (2018): 845-856
Gan, C. S., C. W. Wang, and K. S. Tan. "Circulatory microRNA-145 expression
is increased in cerebral ischemia." Genet Mol Res 11.1 (2012): 147-152.