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Manufactured by BioVendor

hsCRP Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:C-Reactive Protein
  • Species:Human
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Cat. No. Size Price


RAP002 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum, Plasma

Sample Requirements

10 μl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

0–10 μg/ml

Limit of Detection

0.02 μg/ml

Summary

Features

  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!

Research topic

Immune Response, Infection and Inflammation, Sepsis

Summary

CRP is an acute-phase protein, produced exclusively in the liver. Serum concentration of CRP increases significantly in cases of both infectious and noninfectious inflammation, of tissue damage and necrosis and in the presence of malignant tumours. CRP is present in the active stages of inflammatory disorders like rheumatoid arthritis, ankylosing spondylitis, Reiter’s syndrome, psoriatic arthropathy, systemic lupus erythematosus, polyarteritis, ulcerative colitis and Crohn’s disease. The CRP level increases dramatically following microbial infections, and this can be particularly helpful for the diagnosis and monitoring of bacterial septicemia in neonates and other immunocompromised patients at risk.

Product References (12)

References

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  • Haidari F, Hojhabrimanesh A, Helli B, Seyedian SS, Ahmadi-Angali K. Effect of a high-protein diet with β-cryptoxanthin supplementation on metabolic riskfactors, oxidative and inflammatory biomarkers in non-alcoholic fatty liverdisease (NAFLD): study protocol for a randomized controlled clinical trial.Trials. 2018 Nov 16;19(1):634. doi: 10.1186/s13063-018-3014-8. PubMed PMID:30445988; PubMed Central PMCID: PMC6240237. See more on PubMed
  • Choi HN, Yim JE. Plasma Adropin as a Potential Marker Predicting Obesity andObesity-associated Cancer in Korean Patients With Type 2 Diabetes Mellitus. JCancer Prev. 2018 Dec;23(4):191-196. doi: 10.15430/JCP.2018.23.4.191. Epub 2018Dec 30. PubMed PMID: 30671402; PubMed Central PMCID: PMC6330988. See more on PubMed
  • Khadir A, Kavalakatt S, Dehbi M, Alarouj M, Bennakhi A, Tiss A, Elkum N. DUSP1Is a Potential Marker of Chronic Inflammation in Arabs with CardiovascularDiseases. Dis Markers. 2018 Dec 13;2018:9529621. doi: 10.1155/2018/9529621.eCollection 2018. PubMed PMID: 30647800; PubMed Central PMCID: PMC6311887. See more on PubMed
  • Khadir A, Kavalakatt S, Madhu D, Hammad M, Devarajan S, Tuomilehto J, Tiss A. Fetuin-A levels are increased in the adipose tissue of diabetic obese humans but not in circulation. Lipids Health Dis. 2018 Dec 22;17(1):291. doi:10.1186/s12944-018-0919-x. PubMed PMID: 30579336; PubMed Central PMCID:PMC6303986. See more on PubMed
  • Salas-Pérez F, Codner E, Valencia E, Pizarro C, Carrasco E, Pérez-Bravo F.MicroRNAs miR-21a and miR-93 are down regulated in peripheral blood mononuclearcells (PBMCs) from patients with type 1 diabetes. Immunobiology. 2013May;218(5):733-7. doi: 10.1016/j.imbio.2012.08.276. Epub 2012 Aug 23. PubMedPMID: 22999472. See more on PubMed
  • Sikorska D, Orzechowska Z, Rutkowski R, Prymas A, Mrall-Wechta M,Bednarek-Hatlińska D, Roszak M, Surdacka A, Samborski W, Witowski J. Diagnosticvalue of salivary CRP and IL-6 in patients undergoing anti-TNF-alpha therapy for rheumatic disease. Inflammopharmacology. 2018 Oct;26(5):1183-1188. doi:10.1007/s10787-018-0515-8. Epub 2018 Jul 24. PubMed PMID: 30043213; PubMedCentral PMCID: PMC6153921. See more on PubMed
  • Perdu S, Castellana B, Kim Y, Chan K, DeLuca L, Beristain AG. Maternal obesitydrives functional alterations in uterine NK cells. JCI Insight. 2016 Jul21;1(11):e85560. doi: 10.1172/jci.insight.85560. PubMed PMID: 27699222; PubMedCentral PMCID: PMC5033901. See more on PubMed
  • Eichelmann F, Weikert C, di Giuseppe R, Biemann R, Isermann B, Schulze MB,Boeing H, Aleksandrova K. Methodological utility of chemerin as a novel biomarkerof immunity and metabolism. Endocr Connect. 2017 Jul;6(5):340-347. doi:10.1530/EC-17-0098. Epub 2017 Jun 7. PubMed PMID: 28592510; PubMed Central PMCID:PMC5510453. See more on PubMed
  • Hasan A, Kochumon S, Al-Ozairi E, Tuomilehto J, Ahmad R. Association betweenAdipose Tissue Interleukin-33 and Immunometabolic Markers in Individuals withVarying Degrees of Glycemia. Dis Markers. 2019 Apr 3;2019:7901062. doi:10.1155/2019/7901062. eCollection 2019. PubMed PMID: 31073344; PubMed CentralPMCID: PMC6470453. See more on PubMed
  • Abu-Farha M, Abubaker J, Al-Khairi I, Cherian P, Noronha F, Kavalakatt S,Khadir A, Behbehani K, Alarouj M, Bennakhi A, Elkum N. Circulatingangiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolicsyndrome. Cardiovasc Diabetol. 2016 Feb 5;15:25. doi: 10.1186/s12933-016-0346-0. PubMed PMID: 26850725; PubMed Central PMCID: PMC4743238. See more on PubMed
  • Koelman L, Pivovarova-Ramich O, Pfeiffer AFH, Grune T, Aleksandrova K.Cytokines for evaluation of chronic inflammatory status in ageing research:reliability and phenotypic characterisation. Immun Ageing. 2019 May 21;16:11.doi: 10.1186/s12979-019-0151-1. eCollection 2019. PubMed PMID: 31139232; PubMedCentral PMCID: PMC6530020. See more on PubMed
Summary References (4)

References to CRP

  • Gewurz H, Mold C, Siegel J, Fiedel B. C-reactive protein and the acute phase response. Adv Intern Med. 1982;27:345-72
  • Helgeson NGP, Adamson DM, Pike RB, James DS, Nicodemus DS, Lee BA, Miller GW. C-Reactive Protein : Laboratory Medicine, Vol. 2 (Race G. J., Ed.). Harper & Row, Hagerstown, chap. 1973;
  • Johnson HL, Chiou CC, Cho CT. Applications of acute phase reactants in infectious diseases. J Microbiol Immunol Infect. 1999 Jun;32 (2):73-82
  • Powell LJ. C-reactive protein--a review. Am J Med Technol. 1979 Feb;45 (2):138-42
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