Serum, Plasma, Cell culture supernatant
Store at 4°C upon arrival for 6 months or -20°C for 12 months.
Limit of Detection
- Intended for Research Use only
- The assay time is less than 5 hours.
- The kit measures BDNF in serum, plasma, cell culture supernatants.
- Assay format is 96 wells
-Components of the kit are provided ready to use, concentrated or lyophilized
Diabetology - Autoimmunity, Energy metabolism and body weight regulation, Neural tissue markers
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4.
However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid
residues and a propeptide of 110 amino acid residues.