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Manufactured by BioVendor

Human Interleukin-6R (CD126) ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA
  • Other names:CD126; gp80; IL-6 R alpha; IL6Q
  • Species:Human
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Cat. No. Size Price


New RGP028R 96 wells
PubMed Product Details
Technical Data

Type

Sandwich ELISA

Applications

Serum, Plasma-EDTA, Plasma-Heparin, Plasma-Citrate, Cell culture supernatant

Storage/Expiration

2–8°C

Calibration Range

31,25-1000 pg/ml

Intra-assay (Within-Run)

CV - 1,4%

Inter-assay (Run-to-Run)

CV - 2,76%

Spiking Recovery

96%

Summary

Research topic

Autoimmunity, Immunology, Oncology

Summary

Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response.
The receptor complex mediating the biological activities consists of two distinct membrane-bound glycoproteins:

  • IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. It binds IL-6 with low affinity
  • A signal-transducing non-ligand binding 130 kDa component (gp130) that is required for high-affinity binding complex (Kd = 50 pM)
    Soluble IL-6 receptor (sIL-6R) is a 50-55 kDa ligand binding protein, derived from the extracellular part of the gp80 receptor by either proteolytic cleavage or by alternative splicing. The soluble form of IL-6R can bind its ligand and induce cellular responses by association with gp130, thus acting as an IL-6 agonist. Dysregulated production of IL6 and its receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Elevated IL-6 concentrations have been reported in numerous clinical disorders where they appear to orchestrate a variety of inflammatory responses.
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