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Manufactured by BioVendor

HVEM-Fc Human Hi-5 Insect cells

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:Hi-5 Insect cells
  • Other names:HVEM, TNFSFR14, ATAR, TR2
  • Species:Human
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Cat. No. Size Price

RBG10178020 20 µg
RBG10178100 100 μg
RBG10178200 200 µg
PubMed Product Details
Technical Data


Recombinant protein


HVEM belongs to the TNF Receptor superfamily of transmembrane proteins, and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues, including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade that results in the induction of transcription factors NF-κB and AP-1. LIGHT (TNFSF14) and TNF-β (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a “receptor decoy” resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-β. Recombinant human HVEM-Fc Chimera is a 376 amino acid fusion protein that contains an N-terminal domain corresponding to the extracellular region of HVEM, and a C-terminal domain corresponding to residues 102 to 330 of human IgG1. The calculated molecular weight of Recombinant Human HVEM-Fc is 41.4 kDa.

Amino Acid Sequence



Hi-5 Insect cells



Biological Activity

Determined by its ability to neutralize 0.25 ng/ml of hTNFβ; induced cytotoxicity on murine L929 cells. The expected ED 50 for this effect is 1.3–1.9 µg/ml of HVEM-Fc.


Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).


Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1–1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at-20°C to –80°C.




Research topic


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