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KL-6 Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:Sialylated Carbohydrate Antigen, Krebs von den Lungen-6
  • Species:Human
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Cat. No. Size Price


RSCYK243882R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum

Sample Requirements

10 μl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

201–4020 U/mL

Limit of Detection

1 U/ml (with 2SD method)

Summary

Research topic

Immune Response, Infection and Inflammation, Pulmonary diseases

Summary

KL-6, a mucinous high-molecular weight glycoprotein, expressed on type II pneumonocytes, is elevated in the serum of patients with active interstitial pneumonia.

References to Product

References

  • Choi S, Won YL, Kim D, Yi GY, Park JS, Kim EA. Subclinical interstitial lung damage in workers exposed to indium compounds. Ann Occup Environ Med. 2013;25(1):24. Published 2013 Oct 21. doi:10.1186/2052-4374-25-24
  • Chou CW, Chao HS, Lin FC, Tsai HC, Yuan WH, Chang SC. Clinical Usefulness of HRCT in Assessing the Severity of Pneumocystis jirovecii Pneumonia: A Cross-sectional Study. Medicine (Baltimore). 2015;94(16):e768.
  • Fatkhutdinova LM, Khaliullin TO, Vasil'yeva OL, et al. Fibrosis biomarkers in workers exposed to MWCNTs. Toxicol Appl Pharmacol. 2016;299:125-31.
  • Guo WL, Zhou ZQ, Chen L, et al. Serum KL-6 in pulmonary alveolar proteinosis: China compared historically with Germany and Japan. J Thorac Dis. 2017;9(2):287-295
  • Shu LH, Lu Q, Han LY, Dong GH. SP-D, KL-6, and HTI-56 levels in children with mycoplasma pneumoniae pneumonia. Int J Clin Exp Pathol. 2015;8(9):11185-91. Published 2015 Sep 1.
  • Sugino K, Shimizu H, Nakamura Y, Isshiki T, Matsumoto K, Homma S. Clinico-radiological features and efficacy of anti-fibrotic agents in atypical idiopathic pulmonary fibrosis. J Thorac Dis. 2018;10(2):899-908.
References to Summary

References to KL-6

  • Arase Y, Ikeda K, Suzuki Y, Kobayashi M, Suzuki F, Akuta N, Sezaki H, Hosaka T, Yatsuji H, Kawamura Y, Kobayashi M, Kumada H. Serum KL-6 level is elevated in chronic hepatitis C patients with combination therapy of pegylated interferon and ribavirin. Intern Med. 2007;46 (15):1155-60
  • Fujiwara Y, Kiura K, Toyooka S, Hotta K, Tabata M, Takigawa N, Soh J, Tanimoto Y, Kanehiro A, Kato K, Date H, Tanimoto M. Elevated serum level of sialylated glycoprotein KL-6 predicts a poor prognosis in patients with non-small cell lung cancer treated with gefitinib. Lung Cancer. 2008 Jan;59 (1):81-7
  • Hamada H, Kohno N, Akiyama M, Hiwada K. Monitoring of serum KL-6 antigen in a patient with radiation pneumonia. Chest. 1992 Mar;101 (3):858-60
  • Kida Y, Maeshima E, Furukawa K, Ichikawa T, Goda M, Ichinose M. A case of polymyositis with a significantly high level of KL-6 associated with pancreatic cancer. Mod Rheumatol. 2007;17 (3):262-4
  • Kikuchi N, Ishii Y, Ohtsuka M. Serum KL-6 levels and acute lung inflammation. Intern Med. 2007;46 (6):335; author reply 337
  • Kobayashi J, Kitamura S. KL-6: a serum marker for interstitial pneumonia. Chest. 1995 Aug;108 (2):311-5
  • Kobayashi J, Kitamura S. Serum KL-6 for the evaluation of active pneumonitis in pulmonary sarcoidosis. Chest. 1996 May;109 (5):1276-82
  • Kohno N, Akiyama M, Kyoizumi S, Hakoda M, Kobuke K, Yamakido M. Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma. Jpn J Clin Oncol. 1988 Sep;18 (3):203-16
  • Kohno N, Awaya Y, Oyama T, Yamakido M, Akiyama M, Inoue Y, Yokoyama A, Hamada H, Fujioka S, Hiwada K. KL-6, a mucin-like glycoprotein, in bronchoalveolar lavage fluid from patients with interstitial lung disease. Am Rev Respir Dis. 1993 Sep;148 (3):637-42
  • Kohno N, Hamada H, Fujioka S, Hiwada K, Yamakido M, Akiyama M. Circulating antigen KL-6 and lactate dehydrogenase for monitoring irradiated patients with lung cancer. Chest. 1992 Jul;102 (1):117-22
  • Kohno N, Kyoizumi S, Awaya Y, Fukuhara H, Yamakido M, Akiyama M. New serum indicator of interstitial pneumonitis activity. Sialylated carbohydrate antigen KL-6. Chest. 1989 Jul;96 (1):68-73
  • Kohno N, Kyoizumi S, Tanabe M, Oyama T, Vossler M, Yamakido M, Akiyama M. Detection of a circulating tumor-associated antigen with a murine monoclonal antibody, LISA 101, selected by reversed indirect enzyme-linked immunosorbent assay. Cancer Res. 1989 Jun 15;49 (12):3412-9
  • Kunitake R, Kuwano K, Yoshida K, Maeyama T, Kawasaki M, Hagimoto N, Hara N. KL-6, surfactant protein A and D in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. Respiration. 2001;68 (5):488-95
  • Ohtsuki Y, Nakanishi N, Fujita J, Yoshinouchi T, Kobayashi M, Ueda N, Lee GH, Furihata M. Immunohistochemical distribution of SP-D, compared with that of SP-A and KL-6, in interstitial pneumonias. Med Mol Morphol. 2007 Sep;40 (3):163-7
  • Tang W, Guo Q, Qu X, Inagaki Y, Seyama Y, Midorikawa Y, Gai R, Kokudo N, Sugawara Y, Nakata M, Makuuchi M. KL-6 mucin is a useful immunohistochemical marker for cholangiocarcinoma. Oncol Rep. 2007 Apr;17 (4):737-41
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