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Manufactured by BioVendor

Macrophage Migration Inhibitory Factor Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:GLIF, MMIF, GIF, Glycosylation-inhibiting factor, MIF
  • Species:Human
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Cat. No. Size Price


RD193443200CS 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Plasma (EDTA, citrate, heparin)

Sample Requirements

10 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box)

Calibration Curve

Calibration Range

1.125–8 ng/ml

Summary

Features

  • It is intended for research use only
  • The total assay time is less than 5 hours
  • The kit measures MIF in human serum and plasma (EDTA, citrate, heparin)
  • Assay format is 96 wells
  • Standard is a recombinant protein produced in E.coli
  • Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Autoimmunity, Cytokines and chemokines and related molecules, Oncology

Summary

The macrophage migration inhibitory factor (MIF) gene, located on 22q11.2, encodes a multifunctional cytokine, MIF, which is produced by several types of cells, including epithelial cells and cells that participate in the innate and adaptive immune responses. MIF is known to mediate certain cell-mediated immune responses, immune regulation, and inflammation. Overexpression and secretion of MIF help restore macrophage cytokine production and T cell activity in response to the immunosuppressive effects of glucocorticoids. Although first described as an immune cell product, a much higher MIF level was found in kinds of human cancer and cancer-prone inflammatory diseases, including chronic pancreatitis and pancreatic cancer. In addition, many functions of MIF support its potential involvement in diabetes, such as MIF inhibits INS-1 cell proliferation. MIF is a pleiotropic proinflammatory cytokine produced by many cell types such as: T lymphocytes, monocytes/macrop­hages, vascular endothelia. It is also released from the pituitary which suggests that MIF is also an endocrine factor. Because of its widespread properties it is a crucial mediator of many immune and autoimmune diseases such as: juvenile idiopathic arthritis (JIA), Crohn disease, diabetes type 1, glomerulonephritis, septic shock, inflammatory lung disease and cancer.

References to Summary

References to Macrophage Migration Inhibitory Factor

  • Liu YH, Chen CC, Yang CM, Chen YJ, Tsai FJ. Dual effect of a polymorphism in the macrophage migration inhibitory factor gene is associated with new-onset Graves disease in a Taiwanese Chinese population. PLoS One. 2014;9 (3):e92849
  • Swierczewska M, Ostalska-Nowicka D, Kempisty B, Szczepankiewicz A, Nowicki M. Polymorphic variants of MIF gene and prognosis in steroid therapy in children with idiopathic nephrotic syndrome. Acta Biochim Pol. 2014;61 (1):67-75
  • Tan L, Ye X, Zhou Y, Yu M, Fu Z, Chen R, Zhuang B, Zeng B, Ye H, Gao W, Lin Q, Li Z, Zhou Q, Chen R. Macrophage migration inhibitory factor is overexpressed in pancreatic cancer tissues and impairs insulin secretion function of beta-cell. J Transl Med. 2014;12:92
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