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Manufactured by BioVendor

MANF Human E. coli

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:E. coli
  • Other names:Mesencephalic Astrocyte-derived Neurotrophic Factor, ARMET, Arginine-rich protein (ARP)
  • Species:Human
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Cat. No. Size Price

RBG10209005 5 µg
RBG10209025 25 µg
RBG10209100 100 μg
PubMed Product Details
Technical Data


Recombinant protein


MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF and its structural homolog CDNF each contain a N-terminal, saposin-like, lipid-binding domain, and a carboxyl-terminal domain that is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's di­sease. Recombinant Human MANF is an 18.1 kDa protein consisting of 158 amino acids, including 8 cysteine residues.

Amino Acid Sequence



E. coli



Biological Activity

Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED 50 for this effect is 15–25 µg/ml.


Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).


Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1–1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at –20°C to –80°C.




Research topic

Neural tissue markers

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