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Matrix Metalloproteinase-2 (MMP-2) Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:MMP-2
  • Species:Human
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Cat. No. Size Price


RD194440200CS 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Plasma-EDTA

Sample Requirements

20 µl/well

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box)

Calibration Curve

Calibration Range

12.5–200 ng/ml

Summary

Features

  • It is intended for research use only
  • The total assay time is less than hours
  • The kit measures REG4 in human EDTA plasma
  • Assay format is 96 wells
  • Standard is a recombinant protein produced in CHO cells
  • Components of the kit are provided ready to use, concentrated or lyophilized

Research topic

Neural tissue markers, Oncology, Others

Summary

Matrix metalloproteinases (MMPs) are zinc- and calciumdependent proteolytic enzymes. MMPs can digest extracellular matrix proteins, such as collagen and fibronectin, and many other proteins, such as proteinases, growth factors, cytokines, chemokines, and cell receptors and thus regulate their activities. MMP was first identified in 1962, and since then, other MMPs have been identified. Interestingly, whereas many MMPs are secreted by cells, others are anchored on cellular membranes. Members of this family play important roles in various cellular processes, such as migration, differentiation, and proliferation. Furthermore, they have been associated with pathophysiologies of various diseases, such as cancer, atherosclerosis, and arthritis.
MMP2 (matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)) is a protein-coding gene. MMP2 codes for a gelatinase that cleaves type IV collagen, a major component of basement membrane.
Elevated expression of MMP-2, along with MMP-9 is usually seen in invasive and highly tumorigenic cancers such as colorectal tumors, gastric carcinoma, pancreatic carcinoma, breast cancer, oral cancer, melanoma, malignant gliomas, Chondrosarcoma, gastrointestinal adenocarcinoma. Levels are also increased in malignant astrocytomas, carcinomatous meningitis, and brain metastases.

Clinical use and areas of investigation:

  • Cancer
  • Traumatic and viral brain injury
References to Product

References

  • Hadisaputra W, Prayudhana S. Serum biomarker profiles of interleukin-6, tumor necrosis factoralpha, matrix-metalloproteinase-2, and vascular endothelial growth factor in endometriosis staging. Med J Indones. 2013;22 (2):76-82
References to Summary

References to Matrix Metalloproteinase-2

  • Ekbote AV, Danda S, Zankl A, Mandal K, Maguire T, Ungerer K. Patient with mutation in the matrix metalloproteinase 2 (MMP2) gene - a case report and review of the literature. J Clin Res Pediatr Endocrinol. 2014;6 (1):40-6
  • Han ME, Baek S, Kim HJ, Lee JH, Ryu SH, Oh SO. Development of an aptamer-conjugated fluorescent nanoprobe for MMP2. Nanoscale Res Lett. 2014;9 (1):104
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