Sandwich ELISA, Biotin-labelled antibody
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box)
- It is intended for research use only
- The total assay time is less than hours
- The kit measures REG4 in human EDTA plasma
- Assay format is 96 wells
- Standard is a recombinant protein produced in CHO cells
- Components of the kit are provided ready to use, concentrated or lyophilized
Neural tissue markers, Oncology, Others
Matrix metalloproteinases (MMPs) are zinc- and calciumdependent proteolytic enzymes. MMPs can digest extracellular matrix proteins, such as collagen and fibronectin, and many other proteins, such as proteinases, growth factors, cytokines, chemokines, and cell receptors and thus regulate their activities. MMP was first identified in 1962, and since then, other MMPs have been identified. Interestingly, whereas many MMPs are secreted by cells, others are anchored on cellular membranes. Members of this family play important roles in various cellular processes, such as migration, differentiation, and proliferation. Furthermore, they have been associated with pathophysiologies of various diseases, such as cancer, atherosclerosis, and arthritis.
MMP2 (matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)) is a protein-coding gene. MMP2 codes for a gelatinase that cleaves type IV collagen, a major component of basement membrane.
Elevated expression of MMP-2, along with MMP-9 is usually seen in invasive and highly tumorigenic cancers such as colorectal tumors, gastric carcinoma, pancreatic carcinoma, breast cancer, oral cancer, melanoma, malignant gliomas, Chondrosarcoma, gastrointestinal adenocarcinoma. Levels are also increased in malignant astrocytomas, carcinomatous meningitis, and brain metastases.
Clinical use and areas of investigation:
- Traumatic and viral brain injury