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ZG16 (Zymogen granule protein 16, Secretory lectin ZG16)

Zymogen granule membrane protein 16 (ZG16) is a 16 kDa protein first identified by immunoscreening of a rat pancreatic cDNA expression library with a polyspecific antiserum raised against purified zymogen granule membranes (ZGM). ZG16 displays sequence homology especially in the carbohydrate recognition domain to the plant lectin jacalin, which recognizes terminal galactose attached to N-acetylgalactosamine by a β1–3 linkage. According to its sequence homology with this lectin, ZG16 was considered a secretory lectin ZG16. Sequence analyses uncovered that ZG16 is highly conserved amongst mammals and is also present in many other species. Rat ZG16 was found to be highly expressed in the pancreas where the protein is localized in the zymogen granule of pancreas, colon, and duodenum. Previous reports indicated that rat ZG16 took part in the formation of zymogen granule by mediating the digestive enzymes to the zymogen granule membrane in pancreatic acinar cells. Human ZG16 was shown to be highly expressed in the adult liver and moderately expressed in intestine (jejunum, ileum) and colon. Moreover, ZG16 is also weakly expressed in the pedunculus cerebellaris but not in other brain’s regions. Owing to the specific expression pattern in the liver, ZG16 was evaluated in hepatocellular carcinoma (HCC), a common cancer worldwide. It was found that human ZG16 was significantly down-regulated in HCC. ZG16 protein also plays a role in the secretion of several glycoproteins. The secretion of human ZG16 was affected when the synthesis of glycans was inhibited with either an inhibitor or by the lack of glucose in cell culture.



Find more on ZG16 on pubmed


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