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osteomiR™ kit

  • Regulatory status:RUO
  • Type:qPCR diagnostic test
  • Species:Human
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New KT-011-OT Analysis of 48 samples
PubMed Product Details
Technical Data

Type

qPCR diagnostic test

Description

The osteomiR TM kit enables the simple and standardized analysis of specific circulating microRNAs in human serum and plasma, which reflect bone quality.

The kit contains 19 individual bone-related biomarkers which

  • are associated to bone microstructure and histomorphometry
  • are significantly regulated in patients with osteoporotic fractures
  • are BMD-independent risk factors for osteoporotic fracture
  • regulate bone formation and resorption via multiple pathways
  • are novel biomarkers for bone disease, which can easily be detected in serum and plasma

All-In-One kit: the osteomiR TM kit includes all reagents for the RNA extraction, cDNA synthesis, Preparation of PCR Mix, real time PCR analysis, data analysis: tailored software.

Applications

Serum, Plasma

Sample Requirements

200 µl

Summary

Features

Low sample volume:
200 µL human serum/plasma

Fracture risk analysis utilizing the osteomiR™ signature:
19 osteomiRs™ and
5 controls/sample

Reduced hands-on time:
primer coated 96 or 384 well plates

High throughput:
analysis of up to 48 samples (4 samples/plate, one kit includes 12 plates)

Fast and simple data analysis:
osteomiR™ software included to obtain normalized data and a fracture-risk score

References to Summary

References to bone quality - related miRNA

  • Anastasilakis AD et al. Changes of Circulating MicroRNAs in Response to Treatment With Teriparatide or Denosumab in Postmenopausal Osteoporosis. J Clin Endocrinol Metab. 2018 Mar 1;103(3):1206-1213.
  • Feichtinger X, et al. Bone-related Circulating MicroRNAs miR-29b-3p, miR550a-3p, and miR-324-3p and their Association to Bone Microstructure and Histomorphometry. Sci. Rep. 2018 20;8(1):4867.
  • Kocijan R, Muschitz C, et al. Circulating microRNA signatures in patients with idiopathic and postmenopausal osteoporosis and fragility fractures. J Clin Endocrinol Metab. 2016 Aug 23.
  • Heilmeier U, Hackl M, et al. Serum microRNAs are indicative of skeletal fractures in postmenopausal women with and without type-2 diabetes and infl uence osteogenic and adipogenic diff erentiation of adipose-tissue derived mesenchymal stem cells in vitro. J Bone Miner Res 2016 Jun 27.
  • Mäkitie RE, Hackl M, et al. Altered MicroRNA Profi le in Osteoporosis Caused by Impaired WNT Signaling. JCEM 2018 ;Mar 1.
  • Kocijan et al., Time-dependent Analysis of microRNAs and Bone Microstructure under consideration of Anti-osteoporotic Treatment. Unpublished
  • Weilner S, et al. Secreted microvesicular miR-31 inhibits osteogenic diff erentiation of mesenchymal stem cells. Aging Cell 2016; 1–11.
  • Li D, et al, Osteoclast-derived exosomal miR 214-3p inhibits osteoblastic bone formation. Nat Commun, 2016, Mar 7;7:10872.
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