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Manufactured by BioVendor

PDGF-AB Human E. coli

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:E. coli
  • Other names:Platelet-Derived Growth Factor-AB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF), PCGF
  • Species:Human
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Cat. No. Size Price


RBG10266002 2 µg
RBG10266010 10 µg
RBG10266100 100 μg
PubMed Product Details
Technical Data

Type

Recombinant protein

Description

PDGFs are disulfide-linked dimers consisting of two 12.0–13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-AB is a 26.4 kDa disulfide-linked dimer, consisting of one α chain and one β chain (234 total amino acids).

Source

E. coli

Purity

98%

Biological Activity

The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is 1 ng/ml, corresponding to a specific activity of 1×106 units/mg.

Endotoxin

Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1–1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at –20°C to –80°C

Storage/Expiration

 –20°C

Summary

Research topic

Bone and cartilage metabolism, Cardiovascular disease, Coronary artery disease, Immune Response, Infection and Inflammation, Neural tissue markers, Oncology

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