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Manufactured by BioVendor

PECAM-1 Human HEK293 cells

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:HEK293 cells
  • Other names:Platelet endothelial cell adhesion molecule, EndoCAM, CD31 antigen, Leukocyte surface protein
  • Species:Human
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Cat. No. Size Price

RBG10269010 10 µg
RBG10269050 50 µg
RBG10269100 100 μg
PubMed Product Details
Technical Data


Recombinant protein

Amino Acid Sequence



HEK293 cells



Biological Activity

Determined by its ability to support the adhesion of activated Jurkat cells. The expected ED50 for this effect is 1.0 –1.5 µg/ml.


Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).


Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1–1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at –20°C to –80°C




Research topic

Cell adhesion proteins, Oncology


PECAM-1 (platelet endothelial cell adhesion molecule-1) also called CD31 and EndoCAM is a newly characterized adhesion molecule that belongs to the immunoglobulin superfamily [14]. PECAM-1 is a transmembrane glycoprotein with a molecular weight of approximately 130 kDa, depending on the degree of glycosylation. PECAM-1 is constitutively expressed on all vascular cells and has provided a useful immunohistochemical marker of blood vessels, particularly in the setting of angiogenesis. It has also been found on platelets, monocytes, neutrophils and CD8+ T cells. Bone marrow stem cells and transformed cell lines of the myeloid and megakaryocytic lineage also express PECAM-1. Interestingly, PECAM-1 was also detected on human, mouse and rat solid tumor lines . Recent studies suggest a role for PECAM-1 in the inflammatory process and leukocyte-endothelial interaction. The process of leukocyte emigration to the site of inflammation can be dissected into three successive stages: rolling, mediated by the selectins; tight adhesion mediated by ICAMs and their counter-receptors, the integrins; and transmigration of leukocytes through intercellular junctions of vascular endothelial cells which requires PECAM-1. PECAM-1 appears to be able to interact both with itself (homophilic binding) and with other “non-PECAM-1” molecules (heterophilic binding). PECAM-1 is an early and sensitive marker for tumor-induced angiogenesis. Several data have suggested that PECAM-1 may be involved in the process of angiogenesis in a developing vertebrate embryo as well as during metastases formation. Besides the membrane-bound form of PECAM-1 a soluble form of the molecule exists, which is 5–10 kDa smaller than cell-associated PECAM-1, and contains the cytoplasmic tail. This form of soluble PECAM-1 is encoded by an alternatively spliced mRNA from which the exon containing the transmembrane domain has been removed. Soluble PECAM-1 was detected in normal human plasma. Antibodies against PECAM-1 have been shown to exhibit a high degree of sensitivity and specificity for endothelial cells in normal, inflammatory and neoplastic tissue. PECAM-1 is a sensitive and specific marker for detection of melanoma-associated angiogenesis. Thus, PECAM-1 may be a useful marker for early detection of tumor metastasis. Compared to normal gut, there is a significant increase of PECAM-1-positive vessels in the mucosa of uninvolved ulcerative colitis. In gingivitis and periodontitis lesion the expression of PECAM-1 on mononuclear infiltrates increases significantly with increasing size of infiltrate.

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