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Manufactured by BioVendor

Perforin Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Species:Human
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Cat. No. Size Price


RGP021R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Cell culture supernatant, Buffer solution

Sample Requirements

100 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

62.5–2000 pg/ml

Limit of Detection

< 40 pg/ml

Summary

Research topic

Apoptosis

Summary

Perforin has structural and functional similarities to complement component 9 (C9). Like C9, Perforin creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood.

Product References (5)

References

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  • Chiossone L, Vitale C, Cottalasso F, Moretti S, Azzarone B, Moretta L, MingariMC. Molecular analysis of the methylprednisolone-mediated inhibition of NK-cellfunction: evidence for different susceptibility of IL-2- versus IL-15-activatedNK cells. Blood. 2007 May 1;109(9):3767-75. Epub 2007 Jan 18. PubMed PMID:17234744. See more on PubMed
  • Klotz JH, Dorn PL, Logan JL, Stevens L, Pinnas JL, Schmidt JO, Klotz SA."Kissing bugs": potential disease vectors and cause of anaphylaxis. Clin InfectDis. 2010 Jun 15;50(12):1629-34. doi: 10.1086/652769. PubMed PMID: 20462351. See more on PubMed
  • Lagadari M, Truta-Feles K, Lehmann K, Berod L, Ziemer M, Idzko M, Barz D,Kamradt T, Maghazachi AA, Norgauer J. Lysophosphatidic acid inhibits thecytotoxic activity of NK cells: involvement of Gs protein-mediated signaling. IntImmunol. 2009 Jun;21(6):667-77. doi: 10.1093/intimm/dxp035. Epub 2009 May 21.PubMed PMID: 19461126. See more on PubMed
  • Stary G, Bangert C, Tauber M, Strohal R, Kopp T, Stingl G. Tumoricidalactivity of TLR7/8-activated inflammatory dendritic cells. J Exp Med. 2007 Jun11;204(6):1441-51. Epub 2007 May 29. PubMed PMID: 17535975; PubMed Central PMCID:PMC2118597. See more on PubMed
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