Select country set
Menu Shopping cart 0,00 Search
Manufactured by BioVendor

Persephin Murine E. coli

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:E. coli
  • Other names:PSP, PSPN
  • Species:Murine
Please select your region to see available products and prices.
Cat. No. Size Price

RBG20110005 5 µg
RBG20110020 20 µg
RBG20110100 100 μg
PubMed Product Details
Technical Data


Recombinant protein


Persephin is a disulfide-linked, homodimeric, neurotrophic factor structurally related to GDNF, artemin, and neurturin. These proteins belong to the cysteine knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR α (α1-α4) receptors. The GFRα4 was first identified in chicken, and was later shown to be the preferential binding subunit for persephin. Persephin promotes the survival of ventral midbrain dopaminergic neurons and motor neurons after sciatic nerve oxotomy, and, like GDNF, promotes ureteric bud branching. However, in contrast to GDNF and neurturin, persephin does not support the survival of peripheral neurons. Recombinant Murine Persephin is a disulfide-linked homodimer, composed of two 10.3 kDa polypeptide chains (192 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-chain disulfide bridging, and the others are involved in the intramolecular ring formation known as the cysteine knot configuration.

Amino Acid Sequence



E. coli



Biological Activity

The ED50 was determined by its ability to stimulate proliferation of human thyroid carcinoma cells (TT cells) is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1×107 units/mg.


Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).


Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1–1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at-20°C to –80°C.




Research topic

Neural tissue markers, Animal studies

Related Products Docs