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Aldosterone ELISA

Product of BioVendor
Product: Size:
New: RCD030R (regulatory status: RUO) 96 wells (1 kit)
Files: Datasheet PDF (RUO) Aldosterone on pubmed

Product details


Summary

Aldosterone is a potent mineral corticoid whose synthesis and release are controlled by the renin-angiotensin system of the body. Aldosterone promotes the reabsorption of sodium in the distal tubules of the kidney resulting in potassium secretion along with sodium retention, which controls the circulating blood volume. Chronic overproduction and secretion of aldosterone leads to hypertension. Measurement of aldosterone levels in serum in conjunction with plasma renin levels can be used to differentiate between primary and secondary aldosteronism.

Research topic

Blood pressure regulation and NO metabolism, Steroid hormones


Assay format

Competitive ELISA

Applications

Plasma, Serum, Urine

Sample requirements

50 µL

Storage/Shipping

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration range

15–1000 pg/ml

Limit of detection

9.1 pg/ml


References to summary

  • Al-Dujaili EA, Edwards CR. Optimization of a direct radioimmunoassay for plasma aldosterone. J Steroid Biochem. 1981 May;14 (5):481-7
  • Cartledge S, Lawson N. Aldosterone and renin measurements. Ann Clin Biochem. 2000 May;37 ( Pt 3):262-78
  • Check JH, Ubelacker L, Lauer CC. Falsely elevated steroidal assay levels related to heterophile antibodies against various animal species. Gynecol Obstet Invest. 1995;40 (2):139-40
  • Corry DB, Tuck ML. Secondary aldosteronism. Endocrinol Metab Clin North Am. 1995 Sep;24 (3):511-29
  • Himathongkam T, Dluhy RG, Williams GH. Potassim-aldosterone-renin interrelationships. J Clin Endocrinol Metab. 1975 Jul;41 (1):153-9
  • Lun S, Espiner EA, Nicholls MG, Yandle TG. A direct radioimmunoassay for aldosterone in plasma. Clin Chem. 1983 Feb;29 (2):268-71
  • Miller MA, Sagnella GA, MacGregor GA. Extraction method and nonextracted kit method compared for measuring plasma aldosterone. Clin Chem. 1997 Oct;43 (10):1995-7
  • Oelkers W, Diederich S, Bahr V. Diagnosis and therapy surveillance in Addison's disease: rapid adrenocorticotropin (ACTH) test and measurement of plasma ACTH, renin activity, and aldosterone. J Clin Endocrinol Metab. 1992 Jul;75 (1):259-64
  • Sequeira SJ, Loughlin T, Cunningham S, Culliton MT, Hannon S, Heffernan A, McKenna TJ. Evaluation of an aldosterone radioimmunoassay: the renin-angiotensin-aldosterone axis as a function of sex and age. Ann Clin Biochem. 1986 Jan;23 ( Pt 1):65-75
  • Stabler TV, Siegel AL. Chemiluminescence immunoassay of aldosterone in serum. Clin Chem. 1991 Nov;37 (11):1987-9
  • Vallotton MB. Primary aldosteronism. Part I. Diagnosis of primary hyperaldosteronism. Clin Endocrinol (Oxf). 1996 Jul;45 (1):47-52
  • Varsano-Aharon N, Ulick S. Further simplifications in the immunoassay of plasma aldosterone. J Clin Endocrinol Metab. 1974 Aug;39 (2):375-9


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