Human Secretory IgA in Stool Human ELISA

Features

• European Union: for in vitro diagnostic use
• rest of the world :RUO
• For the determination of sIgA in stool
• internal quality control 510 - 2040 µg/ml (reference values)
• limit of detection 3.0 ng/ml

Research topic

Autoimmunity, Immune Response, Infection and Inflammation

Summary

The sIgA consists of two immunoglobulin A molecules, which are connected to each other via a J protein (joining) and a secretory component. The secretory component is synthesized by the epithelial cells of the mucous membranes of the gastrointestinal, respiratory and urogenital tracts, as well as in the salivary, lacrimal and mammary glands. The plasma cells in the subendothelial space of the mucous membranes secrete a complex of two IgA molecules linked via the J protein. This complex then binds to the secretory component that sits on the surface of the epithelial cell. After binding, the sIgA is transported through the epithelial cell and excreted at the mucosal surface by exocytosis. The determination of the secretory IgA (sIgA) provides an initial overview of the functional status of the gut-associated immune system (GALT). Here, the secretion capacity and the degree of stimulation of the plasma cells in the submucosa of the intestine are recorded.Taking non-steroidal anti-inflammatory drugs (e.g. aspirin, ibuprofen, diclofenac) or COX-2 inhibitors (e.g. celecoxib) can lead to enteropathies, which result in an increase in inflammatory parameters in the stool (10). Before carrying out the determination, the corresponding medication should therefore not be taken for a period of 14 days, so as not to influence the measurement of the degree of intestinal inflammation.