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Manufactured by BioVendor

Leptin Receptor Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Species:Human
Cat. No. Size Price


RD194002100 96 wells (1 kit) $590
PubMed Product Details
Technical Data

Type

Sandwich ELISA, HRP-labelled antibody

Applications

Serum, Plasma-EDTA, Plasma-Heparin

Sample Requirements

35 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

2–100 ng/ml

Limit of Detection

Analytical Limit of Detection is calculated from the real Leptin receptor values in wells and is 0.04 ng/ml

Intra-assay (Within-Run)

n = 8; CV = 7.2%

Inter-assay (Run-to-Run)

n = 7; CV = 8.0%

Spiking Recovery

88,60%

Dilution Linearity

107,90%

Crossreactivity

  • bovine Non-detectable
  • cat Non-detectable
  • dog Non-detectable
  • goat Non-detectable
  • horse Non-detectable
  • hamster Not tested
  • monkey Non-detectable
  • mouse Non-detectable
  • pig Non-detectable
  • rabbit Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • human Yes
Summary

Features

  • For research use only !
  • The total assay time is less than four hours.
  • The kit measures total serum Leptin receptor.
  • Standard is recombinat protein based.
  • Quality Controls are human serum based.
  • Components of the kit are ready-to-use (with the exception of Wash Solution and Quality Controls).

Research topic

Diabetology - Other Relevant Products, Energy metabolism and body weight regulation, Reproduction

Summary

Leptin receptor (OB R) was identified as a leptin binding protein (Leptin, the product of the ob gene, is a single chain 16 kDa protein consisting of 146 amino acid residues.) OB R was found to be a member of the class I cytokine receptor family with a large extracellular domain comprising 816 amino acid residues. Leptin receptor exists in multiple forms with a common extracellular domain and a variable length cytoplasmatic portion. Alternate splicing from a single gene derives the six isoforms of the Leptin receptor. The soluble form of the Leptin receptor, OB R contains no intracellular motifs or transmembrane residues, thus it consists entirely of the extracellular ligand binding domain of the receptor. Long forms of OB-R transcripts were reported to be expressed predominantly in regions of the hypothalamus which provides evidence that Leptin receptor is important in body weight regulation. Expression of short forms of OB-R transcripts have been found in multiple tissues, including the choroid plexus, lung, kidney, and primitive hematopoietic cell populations. Leptin receptor may act as a negative regulator of Leptin activity and it may maintain a pool of available bioactive Leptin by binding and delaying its clearance from circulation. Soluble Leptin receptor levels are indirectly proportional to adiposity and are increased in females versus males. Leptin receptor levels are highest in infants, decrease into adolescence, and remain relatively stable throughout adulthood. Soluble Leptin receptor is also found upregulated in patients with chronic heart failure, end-stage renal disease and anorexia.

Product References (68)

References

  • Czogała W, Strojny W, Schab M, Grabowska A, Miklusiak K, Kowalczyk W, Łazarczyk A, Tomasik P, Skoczeń S. FTO and PLAG1 Genes Expression and FTO Methylation Predict Changes in Circulating Levels of Adipokines and Gastrointestinal Peptides in Children. Nutrients. 2021 Oct 13;13(10):3585. doi: 10.3390/nu13103585. PubMed PMID: 34684585. PubMed CentralPMCID: PMC8538237. See more on PubMed
  • Lewandowski KC, Biesiada L, Grzesiak M, Sakowicz A. C-Peptide and leptin system in dichorionic, small and appropriate for gestational age twins-possible link to metabolic programming?. Nutr Diabetes. 2020 Aug 10;10(1):29. doi: 10.1038/s41387-020-00131-2. PubMed PMID: 32778645. PubMed CentralPMCID: PMC7417567. See more on PubMed
  • Konigorski S, Janke J, Drogan D, Bergmann MM, Hierholzer J, Kaaks R, Boeing H, Pischon T. Prediction of Circulating Adipokine Levels Based on Body Fat Compartments and Adipose Tissue Gene Expression. Obes Facts. 2019;12(6):590-605. doi: 10.1159/000502117. Epub 2019 Nov 7. PubMed PMID: 31698359. PubMed CentralPMCID: PMC6940469. See more on PubMed
  • Trefz P, Schmidt SC, Sukul P, Schubert JK, Miekisch W, Fischer DC. Non-Invasive Assessment of Metabolic Adaptation in Paediatric Patients Suffering from Type 1 Diabetes Mellitus. J Clin Med. 2019 Oct 26;8(11):1797. doi: 10.3390/jcm8111797. PubMed PMID: 31717811. PubMed CentralPMCID: PMC6912469. See more on PubMed
  • Szczepankiewicz D, Sobkowiak P, Narożna B, Wojsyk-Banaszak I, Bręborowicz A, Szczepankiewicz A. Leptin gene polymorphism affects leptin level in childhood asthma. World J Pediatr. 2018 Dec;14(6):601-606. doi: 10.1007/s12519-018-0182-2. Epub 2018 Sep 10. PubMed PMID: 30203371. PubMed CentralPMCID: PMC6208747. See more on PubMed
  • Yin H, Tian S, Huang R, Cai R, Guo D, Lin H, Wang J, Wang S. Low Plasma Leptin and High Soluble Leptin Receptor Levels Are Associated With Mild Cognitive Impairment in Type 2 Diabetic Patients. Front Aging Neurosci. 2018 May 15;10:132. doi: 10.3389/fnagi.2018.00132. eCollection 2018. PubMed PMID: 29867443. PubMed CentralPMCID: PMC5962657. See more on PubMed
  • Olczyk P, Koprowski R, Komosinska-Vassev K, Jura-Półtorak A, Winsz-Szczotka K, Kuźnik-Trocha K, Mencner Ł, Telega A, Ivanova D, Olczyk K. Adiponectin, Leptin, and Leptin Receptor in Obese Patients with Type 2 Diabetes Treated with Insulin Detemir. Molecules. 2017 Jul 30;22(8):1274. doi: 10.3390/molecules22081274. PubMed PMID: 28758947. PubMed CentralPMCID: PMC6152287. See more on PubMed
  • Maciejewska-Paszek I, Grochowska-Niedworok E, Siwiec A, Gruenpeter A, Dul L, Irzyniec T. Influence of etanercept on leptin and ghrelin secretion in children with juvenile idiopathic arthritis. J Int Med Res. 2017 Apr;45(2):525-532. doi: 10.1177/0300060516688340. Epub 2017 Mar 7. PubMed PMID: 28415953. PubMed CentralPMCID: PMC5536652. See more on PubMed
  • Yildizfer F, Donma O, Yen M, Ekmekci O, Karatas Kul ZA, Keser Z, Esat Imal A, Cagil E, Mengi M, Ekmekci H, Sahmay S, Nalbantoglu B, Donma MM. In Vitro Fertilization, Levels of Pro-Inflammatory Factors and Lipid Peroxidation. Int J Fertil Steril. 2015 Oct-Dec;9(3):277-84. doi: 10.22074/ijfs.2015.4541. Epub 2015 Oct 31. PubMed PMID: 26644849. PubMed CentralPMCID: PMC4671383. See more on PubMed
  • Yanni D, Darendeliler F, Bas F, Kucukemre Aydin B, Coban A, Ince Z. The role of leptin, soluble leptin receptor, adiponectin and visfatin in insulin sensitivity in preterm born children in prepubertal ages. Cytokine. 2013 Oct;64(1):448-53. doi: 10.1016/j.cyto.2013.04.034. Epub 2013 May 29. PubMed PMID: 23726672. See more on PubMed
  • Dalamaga M, Karmaniolas K, Chamberland J, Nikolaidou A, Lekka A, Dionyssiou-Asteriou A, Mantzoros CS. Higher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome. Metabolism. 2013 Dec;62(12):1830-9. doi: 10.1016/j.metabol.2013.09.007. Epub 2013 Oct 17. PubMed PMID: 24140093. See more on PubMed
  • Holm JC, Gamborg M, Ward LC, Gammeltoft S, Kaas-Ibsen K, Heitmann BL, Sørensen TI. Tracking of leptin, soluble leptin receptor, and the free leptin index during weight loss and regain in children. Obes Facts. 2011;4(6):461-8. doi: 10.1159/000335121. Epub 2011 Dec 6. PubMed PMID: 22248997. PubMed CentralPMCID: PMC6444820. See more on PubMed
  • Arnold T, Brandlhofer S, Vrtikapa K, Stangl H, Hermann M, Zwiauer K, Mangge H, Karwautz A, Huemer J, Koller D, Schneider WJ, Strobl W. Effect of obesity on plasma clusterin, [corrected] a proposed modulator of leptin action. Pediatr Res. 2011 Mar;69(3):237-42. doi: 10.1203/PDR.0b013e31820930cb. PubMed PMID: 21135756. See more on PubMed
  • Koch A, Weiskirchen R, Zimmermann HW, Sanson E, Trautwein C, Tacke F. Relevance of serum leptin and leptin-receptor concentrations in critically ill patients. Mediators Inflamm. 2010;2010:473540. doi: 10.1155/2010/473540. Epub 2010 Sep 7. PubMed PMID: 20871818. PubMed CentralPMCID: PMC2943118. See more on PubMed
  • Haluzíková D, Dostálová I, Kaválková P, Roubíček T, Mráz M, Papežová H, Haluzík M. Serum concentrations of adipocyte fatty acid binding protein in patients with anorexia nervosa. Physiol Res. 2009;58(4):577-581. doi: 10.33549/physiolres.931575. Epub 2008 Jul 25. PubMed PMID: 18657008. See more on PubMed
  • Thomopoulos C, Papadopoulos DP, Papazachou O, Bratsas A, Massias S, Anastasiadis G, Perrea D, Makris T. Free leptin is associated with masked hypertension in nonobese subjects: a cross-sectional study. Hypertension. 2009 Jun;53(6):965-72. doi: 10.1161/HYPERTENSIONAHA.108.128041. Epub 2009 Apr 27. PubMed PMID: 19398660. See more on PubMed
  • Dostálová I, Kaválková P, Haluzíková D, Lacinová Z, Mráz M, Papezová H, Haluzík M. Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa. J Clin Endocrinol Metab. 2008 Sep;93(9):3627-32. doi: 10.1210/jc.2008-0746. Epub 2008 Jun 17. PubMed PMID: 18559909. See more on PubMed
  • Huang XD, Fan Y, Zhang H, Wang P, Yuan JP, Li MJ, Zhan XY. Serum leptin and soluble leptin receptor in non-alcoholic fatty liver disease. World J Gastroenterol. 2008 May 14;14(18):2888-93. doi: 10.3748/wjg.14.2888. PubMed PMID: 18473416. PubMed CentralPMCID: PMC2710733. See more on PubMed
  • Hoefle G, Saely CH, Risch L, Rein P, Koch L, Schmid F, Aczél S, Marte T, Langer P, Drexel H. Leptin, leptin soluble receptor and coronary atherosclerosis. Eur J Clin Invest. 2007 Aug;37(8):629-36. doi: 10.1111/j.1365-2362.2007.01842.x. PubMed PMID: 17635573. See more on PubMed
  • Proto C, Romualdi D, Cento RM, Romano C, Campagna G, Lanzone A. Free and total leptin serum levels and soluble leptin receptors levels in two models of genetic obesity: the Prader-Willi and the Down syndromes. Metabolism. 2007 Aug;56(8):1076-80. doi: 10.1016/j.metabol.2007.03.016. PubMed PMID: 17618952. See more on PubMed
  • Anderson PD, Mehta NN, Wolfe ML, Hinkle CC, Pruscino L, Comiskey LL, Tabita-Martinez J, Sellers KF, Rickels MR, Ahima RS, Reilly MP. Innate immunity modulates adipokines in humans. J Clin Endocrinol Metab. 2007 Jun;92(6):2272-9. doi: 10.1210/jc.2006-2545. Epub 2007 Mar 20. PubMed PMID: 17374708. See more on PubMed
  • Presle N, Pottie P, Dumond H, Guillaume C, Lapicque F, Pallu S, Mainard D, Netter P, Terlain B. Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilage. 2006 Jul;14(7):690-5. doi: 10.1016/j.joca.2006.01.009. Epub 2006 Mar 9. PubMed PMID: 16527497. See more on PubMed
  • Papadopoulos DP, Makris TK, Poulakou M, Papazachou UG, Hatzizacharias AN, Perrea DN, Votteas VE. Human soluble leptin receptor concentration in healthy offspring of hypertensive parents. J Clin Hypertens (Greenwich). 2006 Nov;8(11):797-802. doi: 10.1111/j.1524-6175.2006.05642.x. PubMed PMID: 17086020. PubMed CentralPMCID: PMC8109730. See more on PubMed
  • Paul G, Schäffler A, Neumeier M, Fürst A, Bataillle F, Buechler C, Müller-Ladner U, Schölmerich J, Rogler G, Herfarth H. Profiling adipocytokine secretion from creeping fat in Crohn's disease. Inflamm Bowel Dis. 2006 Jun;12(6):471-7. doi: 10.1097/00054725-200606000-00005. PubMed PMID: 16775490. See more on PubMed
  • Martos-Moreno GA, Barrios V, Argente J. Normative data for adiponectin, resistin, interleukin 6, and leptin/receptor ratio in a healthy Spanish pediatric population: relationship with sex steroids. Eur J Endocrinol. 2006 Sep;155(3):429-34. doi: 10.1530/eje.1.02227. PubMed PMID: 16914597. See more on PubMed
  • Yiannakouris N, Melistas L, Yannakoulia M, Mungal K, Mantzoros CS. The-2548G/A polymorphism in the human leptin gene promoter region is associated with plasma free leptin levels; interaction with adiposity and gender in healthy subjects. Hormones (Athens). 2003 Oct-Dec;2(4):229-36. doi: 10.14310/horm.2002.11104. PubMed PMID: 17003027. See more on PubMed
  • Verhaeghe J, van Bree R, Van Herck E. Maternal body size and birth weight: can insulin or adipokines do better?. Metabolism. 2006 Mar;55(3):339-44. doi: 10.1016/j.metabol.2005.09.007. PubMed PMID: 16483877. See more on PubMed
  • Stejskal D, Růzicka V, Adamovská S, Juráková R, Prosková J, Jedelský L, Bartek J. Adiponectin concentrations as a criterion of metabolic control in persons with type 2 diabetes mellitus?. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003 Dec;147(2):167-72. doi: 10.5507/bp.2003.023. PubMed PMID: 15037898. See more on PubMed
  • Verhaeghe J, van Bree R, Lambin S, Caluwaerts S. Adipokine profile and C-reactive protein in pregnancy: effects of glucose challenge response versus body mass index. J Soc Gynecol Investig. 2005 Jul;12(5):330-4. doi: 10.1016/j.jsgi.2005.02.002. PubMed PMID: 15979544. See more on PubMed
  • Jarkovská Z, Hodková M, Sazamová M, Rosická M, Dusilová-Sulková S, Marek J, Justová V, Lacinová Z, Haluzík M, Haas T, Krsek M. Plasma levels of active and total ghrelin in renal failure: a relationship with GH/IGF-I axis. Growth Horm IGF Res. 2005 Dec;15(6):369-76. doi: 10.1016/j.ghir.2005.07.004. Epub 2005 Sep 28. PubMed PMID: 16198134. See more on PubMed
  • Zemanová M, Petruzelka L, Pazdrová G, Haluzík M, Novák F, Svobodník A. [Changes in leptin, leptin receptor and fatty acids levels during chemoradiotherapy for oesophageal cancer]. Cas Lek Cesk. 2005;144(12):811-6. PubMed PMID: 16389753. See more on PubMed
  • Szalay F, Folhoffer A, Horváth A, Csak T, Speer G, Nagy Z, Lakatos P, Horváth C, Habior A, Tornai I, Lakatos PL. Serum leptin, soluble leptin receptor, free leptin index and bone mineral density in patients with primary biliary cirrhosis. Eur J Gastroenterol Hepatol. 2005 Sep;17(9):923-8. doi: 10.1097/00042737-200509000-00007. PubMed PMID: 16093869. See more on PubMed
  • Papadopoulos DP, Makris TK, Krespi PG, Poulakou M, Paizis IA, Hatzizacharias AN, Perrea D, Votteas VV. Human soluble leptin receptor number in healthy normotensive individuals with high normal blood pressure. Am J Hypertens. 2005 Jul;18(7):1001-4. doi: 10.1016/j.amjhyper.2005.02.001. PubMed PMID: 16053999. See more on PubMed
  • Tsiotra PC, Pappa V, Koukourava A, Economopoulos T, Tsigos C, Raptis SA. Expression of leptin receptors in mononuclear cells from myelodysplastic syndromes and acute myeloid leukemias. Acta Haematol. 2005;114(2):71-7. doi: 10.1159/000086578. PubMed PMID: 16103628. See more on PubMed
  • Popruk S, Tungtrongchitr R, Pongpaew P, Phonrat B, Tungtrongchitr A, Tribunyatkul S, Paksanont S, Vudhivai N, Schelp FP. Relationship between soluble leptin receptor, leptin, lipid profiles and anthropometric parameters in overweight and obese Thai subjects. J Med Assoc Thai. 2005 Feb;88(2):220-7. PubMed PMID: 15962674. See more on PubMed
  • Housová J, Wilczek H, Haluzík MM, Kremen J, Krízová J, Haluzík M. Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment. Physiol Res. 2005;54(1):73-78. doi: 10.33549/physiolres.930568. PubMed PMID: 15717844. See more on PubMed
  • Chatzantoni K, Papathanassopoulos P, Gourzoulidou E, Mouzaki A. Leptin and its soluble receptor in plasma of patients suffering from remitting-relapsing multiple sclerosis (MS) In vitro effects of leptin on type-1 and type-2 cytokine secretion by peripheral blood mononuclear cells, T-cells and monocytes of MS patients. J Autoimmun. 2004 Sep;23(2):169-77. doi: 10.1016/j.jaut.2004.05.007. PubMed PMID: 15324935. See more on PubMed
  • Housova J, Anderlova K, Krizová J, Haluzikova D, Kremen J, Kumstyrová T, Papezová H, Haluzik M. Serum adiponectin and resistin concentrations in patients with restrictive and binge/purge form of anorexia nervosa and bulimia nervosa. J Clin Endocrinol Metab. 2005 Mar;90(3):1366-70. doi: 10.1210/jc.2004-1364. Epub 2004 Dec 14. PubMed PMID: 15598689. See more on PubMed
  • Wolfe BE, Jimerson DC, Orlova C, Mantzoros CS. Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers. Clin Endocrinol (Oxf). 2004 Sep;61(3):332-8. doi: 10.1111/j.1365-2265.2004.02101.x. PubMed PMID: 15355449. See more on PubMed
  • Nuamah MA, Yura S, Sagawa N, Itoh H, Mise H, Korita D, Kakui K, Takemura M, Ogawa Y, Nakao K, Fujii S. Significant increase in maternal plasma leptin concentration in induced delivery: a possible contribution of pro-inflammatory cytokines to placental leptin secretion. Endocr J. 2004 Apr;51(2):177-87. doi: 10.1507/endocrj.51.177. PubMed PMID: 15118268. See more on PubMed
  • Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem. 2004 Sep;50(9):1511-25. doi: 10.1373/clinchem.2004.032482. Epub 2004 Jul 20. PubMed PMID: 15265818. See more on PubMed
  • Welt CK, Schneyer AL, Heist K, Mantzoros CS. Leptin and soluble leptin receptor in follicular fluid. J Assist Reprod Genet. 2003 Dec;20(12):495-501. doi: 10.1023/b:jarg.0000013649.38415.2a. PubMed PMID: 15035548. PubMed CentralPMCID: PMC3455309. See more on PubMed
  • Lenchik L, Register TC, Hsu FC, Lohman K, Nicklas BJ, Freedman BI, Langefeld CD, Carr JJ, Bowden DW. Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone. 2003 Oct;33(4):646-51. doi: 10.1016/s8756-3282(03)00237-0. PubMed PMID: 14555270. See more on PubMed
  • Buyan N, Ozkaya O, Bideci A, Söylemezoğlu O, Cinaz P, Gönen S, Kalman S, Bakkaloğlu S, Hasanoğlu E. Leptin, soluble leptin receptor, and transforming growth factor-beta1 levels in minimal change nephrotic syndrome. Pediatr Nephrol. 2003 Oct;18(10):1009-14. doi: 10.1007/s00467-003-1221-2. Epub 2003 Jul 29. PubMed PMID: 12898374. See more on PubMed
  • Nuamah MA, Sagawa N, Yura S, Mise H, Itoh H, Ogawa Y, Nakao K, Fujii S. Free-to-total leptin ratio in maternal plasma is constant throughout human pregnancy. Endocr J. 2003 Aug;50(4):421-8. doi: 10.1507/endocrj.50.421. PubMed PMID: 14599116. See more on PubMed
  • Krsek M, Silha JV, Jezková J, Hána V, Marek J, Weiss V, Stepán JJ, Murphy LJ. Adipokine levels in Cushing's syndrome; elevated resistin levels in female patients with Cushing's syndrome. Clin Endocrinol (Oxf). 2004 Mar;60(3):350-7. doi: 10.1111/j.1365-2265.2003.01987.x. PubMed PMID: 15009001. See more on PubMed
  • Krízová J, Sulková S, Bednárová V, Parízková J, Kotrlíková E, Haluzík M. Soluble leptin receptor levels in patients with chronic renal failure. Physiol Res. 2003;52(3):347-51. PubMed PMID: 12790767. See more on PubMed
  • Sandhofer A, Laimer M, Ebenbichler CF, Kaser S, Paulweber B, Patsch JR. Soluble leptin receptor and soluble receptor-bound fraction of leptin in the metabolic syndrome. Obes Res. 2003 Jun;11(6):760-8. doi: 10.1038/oby.2003.106. PubMed PMID: 12805397. See more on PubMed
  • Teplan V, Schück O, Stollová M, Vítko S. Obesity and hyperhomocysteinaemia after kidney transplantation. Nephrol Dial Transplant. 2003 Jul;18 Suppl 5:v71-3. doi: 10.1093/ndt/gfg1053. PubMed PMID: 12817077. See more on PubMed
  • Kado N, Kitawaki J, Koshiba H, Ishihara H, Kitaoka Y, Teramoto M, Honjo H. Relationships between the serum levels of soluble leptin receptor and free and bound leptin in non-pregnant women of reproductive age and women undergoing controlled ovarian hyperstimulation. Hum Reprod. 2003 Apr;18(4):715-20. doi: 10.1093/humrep/deg186. PubMed PMID: 12660261. See more on PubMed
  • Rosická M, Krsek M, Matoulek M, Jarkovská Z, Marek J, Justová V, Lacinová Z. Serum ghrelin levels in obese patients: the relationship to serum leptin levels and soluble leptin receptors levels. Physiol Res. 2003;52(1):61-6. PubMed PMID: 12625808. See more on PubMed
  • Kalousová M, Sulková S, Zima T, Deppisch R, Beck W, Bednárová sV, Fortová M, Tesar V. Advanced glycation end products in hemodialyzed patients with diabetes mellitus correlate with leptin and leptin/body fat ratio. Ren Fail. 2003 Mar;25(2):277-86. doi: 10.1081/jdi-120018728. PubMed PMID: 12739834. See more on PubMed
  • Mann DR, Johnson AO, Gimpel T, Castracane VD. Changes in circulating leptin, leptin receptor, and gonadal hormones from infancy until advanced age in humans. J Clin Endocrinol Metab. 2003 Jul;88(7):3339-45. doi: 10.1210/jc.2002-022030. PubMed PMID: 12843185. See more on PubMed
  • Gavrila A, Peng CK, Chan JL, Mietus JE, Goldberger AL, Mantzoros CS. Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. J Clin Endocrinol Metab. 2003 Jun;88(6):2838-43. doi: 10.1210/jc.2002-021721. PubMed PMID: 12788897. See more on PubMed
  • Haluzik M, Markova M, Slaby JJ, Jiskra J, Krizova J, Hass T. The changes of serum leptin and soluble leptin receptor levels in patients undergoing mobilization of peripheral blood stem cells before autologous stem cells transplantation. Endocr Res. 2002 Aug;28(3):189-97. doi: 10.1081/erc-120015057. PubMed PMID: 12489568. See more on PubMed
  • Yannakoulia M, Yiannakouris N, Blüher S, Matalas AL, Klimis-Zacas D, Mantzoros CS. Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. J Clin Endocrinol Metab. 2003 Apr;88(4):1730-6. doi: 10.1210/jc.2002-021604. PubMed PMID: 12679465. See more on PubMed
  • Pecoits-Filho R, Nordfors L, Heimbürger O, Lindholm B, Anderstam B, Marchlewska A, Stenvinkel P. Soluble leptin receptors and serum leptin in end-stage renal disease: relationship with inflammation and body composition. Eur J Clin Invest. 2002 Nov;32(11):811-7. doi: 10.1046/j.1365-2362.2002.01063.x. PubMed PMID: 12423321. See more on PubMed
  • Monteleone P, Fabrazzo M, Tortorella A, Fuschino A, Maj M. Opposite modifications in circulating leptin and soluble leptin receptor across the eating disorder spectrum. Mol Psychiatry. 2002;7(6):641-6. doi: 10.1038/sj.mp.4001043. PubMed PMID: 12140788. See more on PubMed
  • Laimer M, Ebenbichler CF, Kaser S, Sandhofer A, Weiss H, Nehoda H, Aigner F, Patsch JR. Weight loss increases soluble leptin receptor levels and the soluble receptor bound fraction of leptin. Obes Res. 2002 Jul;10(7):597-601. doi: 10.1038/oby.2002.81. PubMed PMID: 12105280. See more on PubMed
  • Krsek M, Rosická M, Haluzík M, Svobodová J, Kotrlíková E, Justová V, Lacinová Z, Jarkovská Z. Plasma ghrelin levels in patients with short bowel syndrome. Endocr Res. 2002 Feb-May;28(1-2):27-33. doi: 10.1081/erc-120004535. PubMed PMID: 12108787. See more on PubMed
  • Chan JL, Blüher S, Yiannakouris N, Suchard MA, Kratzsch J, Mantzoros CS. Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes. 2002 Jul;51(7):2105-12. doi: 10.2337/diabetes.51.7.2105. PubMed PMID: 12086939. See more on PubMed
  • Ogier V, Ziegler O, Méjean L, Nicolas JP, Stricker-Krongrad A. Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans. Int J Obes Relat Metab Disord. 2002 Apr;26(4):496-503. doi: 10.1038/sj.ijo.0801951. PubMed PMID: 12075576. See more on PubMed
  • Shimizu H, Shimomura K, Negishi M, Masunaga M, Uehara Y, Sato N, Shimomura Y, Kasai K, Mori M. Circulating concentrations of soluble leptin receptor: influence of menstrual cycle and diet therapy. Nutrition. 2002 Apr;18(4):309-12. doi: 10.1016/s0899-9007(01)00787-0. PubMed PMID: 11934542. See more on PubMed
  • Lahlou N, Issad T, Lebouc Y, Carel JC, Camoin L, Roger M, Girard J. Mutations in the human leptin and leptin receptor genes as models of serum leptin receptor regulation. Diabetes. 2002 Jun;51(6):1980-5. doi: 10.2337/diabetes.51.6.1980. PubMed PMID: 12031989. See more on PubMed
  • van Dielen FM, van 't Veer C, Buurman WA, Greve JW. Leptin and soluble leptin receptor levels in obese and weight-losing individuals. J Clin Endocrinol Metab. 2002 Apr;87(4):1708-16. doi: 10.1210/jcem.87.4.8381. PubMed PMID: 11932305. See more on PubMed
  • Manzella D, Parillo M, Razzino T, Gnasso P, Buonanno S, Gargiulo A, Caputi M, Paolisso G. Soluble leptin receptor and insulin resistance as determinant of sleep apnea. Int J Obes Relat Metab Disord. 2002 Mar;26(3):370-5. doi: 10.1038/sj.ijo.0801939. PubMed PMID: 11896492. See more on PubMed
  • Malincíková J, Stejskal D, Hrebícek J. Serum leptin and leptin receptors in healthy prepubertal children: relations to insulin resistance and lipid parameters, body mass index (BMI), tumor necrosis factor alpha (TNF alpha), heart fatty acid binding protein (hFABP), and IgG anticardiolipin (ACL-IgG). Acta Univ Palacki Olomuc Fac Med. 2000;143:51-7. doi: 10.5507/bp.2000.007. PubMed PMID: 11144119. See more on PubMed
  • Stejskal D, Bartek J, Růzicka V, Stejskal P, Jedelský L, Oral I, Horalík D, Zurek M. Determination of leptin receptor in the serum and relations to laboratory and anthropological parameters in patients with atherosclerotic complications. Acta Univ Palacki Olomuc Fac Med. 1999;142:89-92. PubMed PMID: 10743733. See more on PubMed
Summary References (8)

References to Leptin Receptor

  • Lahlou N. et al.: Soluble leptin receptor in serum of subjects with complete resistance to leptin: Diabetes; 19:1347–1352 (2000)
  • Auwerx J. and Staels B.: Leptin (Review article). The Lancet; 13:737 (1998)
  • Chen H. et al.: Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell; 84:491–495 (1996)
  • Ciofii J. A. et al.: Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nature Med.; 2:585–589 (1996)
  • Houseknecht K. L. and Portocarrero C. P.: Leptin and its receptors: Regulators of whole body energy homeostasis. Domestic animal endocrinology; 15 (6):457–475 (1998)
  • Lee G.H. et al.: Abnormal splicing of the leptin receptor in diabetic mice. Nature; 379:632–635 (1996)
  • Tartaglia L. A. et al.: Identification and Expresion Cloning of a Leptin Receptor, OB-R. Cell; 83:1263–1271 (1995)
  • Tartaglia L. A.: The leptin receptor. J. Biol. Chem.; 272:6093–6096 (1997)
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