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Affinity Mass Spectrometry

Mass spectrometry (MS) is an analytical technique that ionizes chemical species and sorts the ions based on their mass to charge ratio. A mass spectrum, a plot of the ion signal as a function of the mass-to-charge ratio, is used to determine the elemental or isotopic signature of a sample, the masses of particles and of molecules, and to elucidate the chemical structures of molecules, such as peptides and other chemical compounds.

Recent developments in biology have enabled the integration of mass spectrometry (MS) and immunoaffinity techniques to detect a protein antigen of interest in a few microliters of human plasma or serum using an antibody functionalized MALDI surface.

The Functionalized MALDI plate is used to selectively enrich the antigen of interest from plasma and/or serum. Bound samples of antigen–antibody complex are reduced and covered by MALDI matrix and the MS spectra are acquired.

As this method of immunoaffinity enrichment combined with MALDI MS is rapid, does not require external purification steps and can be automated it has a great potential to be used in determination of many clinically relevant antigens.



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Human Haptoglobin Phenotype MALDI MS

New: RMS01
(regulatory status: RUO)
48 spots

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