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SARS-CoV-2 (2019-nCoV) Spike Glycoprotein-S2, HEK293 Recombinant

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:HEK293
  • Other names:Severe acute respiratory syndrome coronavirus 2 spike glycoprotein S2, 2019 novel coronavirus S2 protein, SARS-CoV-2 S2 subunit, COVID-19
  • Species:SARS
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Cat. No. Size Price


New RP9720120150 0.15 mg
New RP9720120250 0.25 mg
New RP9720120050 0.05 mg
PubMed Product Details
Technical Data

Type

Recombinant protein

Description

The HEK293 derived recombinant protein contains the SARS-CoV-2 Spike Glycoprotein S2, Wuhan-Hu-1 strain, amino acids 685-1211 fused to Fc tag at C-terminal.

Source

HEK293

Purity

Greater than 85.0% as determined by SDS-PAGE. Purfied by Protein-G chromatographic technique.

Formulation

SARS-CoV-2 S2 protein solution is supplied in DPBS.

Applications

COVID-19

Storage/Expiration

Shipped on ice packs. Store at -20⁰C upon arrival.

Physical Appearance

Sterile filtered clear solution.

Note

BioVendor's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Summary

Research topic

Immune Response, Infection and Inflammation, COVID-19

Summary

Coronaviruses (CoVs), within the order Nidovirales, are enveloped, single-strand, positive-sense RNA viruses with a large genome of approximately 30 kbp in length. A human infecting coronavirus (viral pneumonia) initially known as 2019 novel coronavirus (2019-nCoV) was found in the fish market at the city of Wuhan, Hubei province of China in December 2019. The virus is now named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
SARS-CoV-2 shares an 87% identity to the 2 bat-derived severe acute respiratory syndrome 2018 SARS-CoV-2 located in Zhoushan of eastern China. SARS-CoV-2 has an analogous receptor-BD-structure to that of 2018 SARS-CoV, even though there is a.a. diversity so thus the SARS-CoV-2 might bind to ACE2 receptor protein (angiotensin-converting enzyme 2) in humans.

While bats are possibly the host of SARS-CoV-2, researchers suspect that animal from the ocean sold at the seafood market was an intermediate host. RSCU analysis proposes that the SARS-CoV-2 is a recombinant within the viral spike glycoprotein between the bat coronavirus and an unknown coronavirus.

Coronaviruses contain at least four structural proteins: Spike (S) protein, envelope (E) protein, membrane (M) protein, and nucleocapsid (N) protein.
The spike (S) glycoprotein is a type I transmembrane glycoprotein that plays an important role in mediating viral infection and is common to all HCoVs. The S proteins consist of two subunits, S1 and S2. The S1 subunit binds the cellular receptor through its receptor-binding domain (RBD), followed by conformational changes in the S2 subunit, which allows the fusion peptide to insert into the host target cell membrane. The heptad repeat 1 (HR1) region in the S2 subunit forms a homotrimeric assembly, which exposes three highly conserved hydrophobic grooves on the surface that bind heptad repeat 2 (HR2). This six-helix bundle (6-HB) core structure is formed during the fusion process and helps bring the viral and cellular membranes into close proximity for viral fusion and entry. Thus, the S protein is an important target protein for the development of specific drugs.

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