Sandwich ELISA, Biotin-labelled antibody
At ambient temperature. Upon receipt, store the product at the temperature recommended below.
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Limit of Detection
CV = 6.0%
CV = 6.5%
- It is intended for research use only
- The total assay time is less than 3.5 hours
- The kit measures human secretagogin in serum and plasma (EDTA)
- Quality Controls are human serum based. No animal sera are used
- Standard is recombinant protein based
- Components of the kit are provided ready to use, concentrated or lyophilized
Diabetology - Other Relevant Products, Neural tissue markers, Oncology
Secretagogin (SCGN, SEGN, CALBL, setagin) is a Ca-binding protein which consists of six-EF hand Ca-binding domains and is characterised by molecular weight of 32 kDa. Generally, Ca-binding proteins seem to be involved in several pathological conditions in the CNS, such as epilepsy or neurodegenerative disorders, for example Alzheimer´s disease. Secretagogin is expressed in central nervous system, particularly in the cerebellum, pituitary gland and hypotalamus, but also in thalamic tissue. Moreover, recent study shown, that secretagogin is detectable in human serum after ischemic brain damage. The secretagogin mRNA was identified as one of the most abundant transcripts in pancreatic islets, highlighting the potential importance of secretagogin in this tissue.
Secretagogin is down-regulated in pancreatic islets exposed to high concentration of glucose, in human non-functional pituitary adenomas and in adenocarcinomas. These results suggest that secretagogin may be involved in suppressing cell growth, and it has been proposed as a novel biomarker for diagnosis of different forms of cancer. Additionally, its strong expression in insulin secreting cells, its influence on insulin expression
might contribute to insulin homeostasis.
Areas of investigation: Neurodegenerative disease, Brain injury, Insulin secretion and Cancer.