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Manufactured by BioVendor

Slit2-N Human HEK293 cells

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:HEK293 cells
  • Other names:Slit homolog 2 protein, SLIL3
  • Species:Human
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Cat. No. Size Price

RBG10297005 5 µg
RBG10297025 25 µg
RBG10297100 100 μg
PubMed Product Details
Technical Data


Recombinant protein


Slit2 is a member of the Slit family that signals through the Roundabout (Robo) receptor as a repellent for axon guidance and neuronal migration, and also acts as a chemoattractant to vascular endothelial cells and a chemotaxis inhibitor for leukocytes. Slit2 is expressed primarily in the fetal lung, kidney, and adult spinal cord, and to a lesser extent in the adult adrenal gland, thyroid and trachea. Slit2 is initially synthesized as a 1499 amino acid precursor, which is subsequently cleaved into N-terminal and C-terminal fragments, designated as Slit2-N and Slit2-C respectively. The neurodevelopment-related activities, as measured by the ability to repel olfactory bulb axons and to induce branching in dorsal root ganglia axons, are contained only in the N-terminal fragment. Recombinant Human Slit2-N is a 1093 amino acid glycoprotein corresponding to the N-terminal portion of the full length Slit2 precursor, and has a calculated, theoretical molecular weight of 122.35 kDa. Due to glycosylation Slit2-N migrates at an apparent molecular weight of approximately 120.0–140.0 kDa by SDS-PAGE analysis under reducing conditions.

Amino Acid Sequence



HEK293 cells



Biological Activity

Determined by its ability to inhibit MC3T3/E1 osteoblasts cell differentiation.


Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).


Centrifuge the vial prior to opening. Reconstitute in 20mM Tris, pH 8.8 + 150mM NaCl to a concentration of 0.1–1.0mg/ml. Note: Slow to dissolve. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at-20°C to –80°C.




Research topic

Chemokines, Cytokines and chemokines and related molecules, Neural tissue markers

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