Sandwich ELISA, Biotin-labelled antibody
Serum, Urine, Plasma (EDTA, citrate, heparin)
At ambient temperature. Upon receipt, store the product at the temperature recommended below.
Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box)
- It is intended for research use only
- The total assay time is less than 3 hours
- The kit measures synuclein-γ in human serum, plasma (EDTA, citrate, heparin) and urine
- Assay format is 96 wells
- Standard is a purified native protein
- Components of the kit are provided ready to use, concentrated or lyophilized
Clinical use and areas of investigation:
- Bladder cancer
- Neural tissue damage
Energy metabolism and body weight regulation, Neural tissue markers, Oncology
The synucleins are a small, soluble, highly conserved group of neuronal proteins that have been implicated in neurodegenerative diseases and cancer. The synuclein family consists of α-, β-, and γ-synuclein (SNCG). Synuclein γ (SNCG) is a human gene localized at 10q23.20 23.3. SNCG cDNA is ~5 kb in length and comprised of five exons that translate into a protein of 127 amino acids. In cooperation with other members of the family γ-synuclein plays role in regulation of dopaminergic neurotransmission. Changes of γ-synuclein expression in peripheral tissues has been linked with metabolic and oncological diseases. The α- and β-synuclein proteins participate in the development and function of the central nervous system, and may be important in the etiology and pathogenesis of neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. SNCG is not clearly involved in neurodegenerative diseases. However, a stage-specific upregulation of SNCG has been found in advanced breast carcinomas and other malignancies, including ovarian, gastric, esophagus, liver, colon, pancreatic, and bladder cancers. γ-Synuclein is highly expressed in human white adipose tissue and increased in obesity.