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Synuclein Gamma Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:SNCG, Synuclein-γ
  • Species:Human
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Cat. No. Size Price


RD191397200CS 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Urine, Plasma (EDTA, citrate, heparin)

Sample Requirements

35 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box)

Calibration Curve

Calibration Range

0.2–10 ng/ml

Summary

Features

  • It is intended for research use only
  • The total assay time is less than 3 hours
  • The kit measures synuclein-γ in human serum, plasma (EDTA, citrate, heparin) and urine
  • Assay format is 96 wells
  • Standard is a purified native protein
  • Components of the kit are provided ready to use, concentrated or lyophilized

Clinical use and areas of investigation:

  • Bladder cancer
  • Neural tissue damage

Research topic

Energy metabolism and body weight regulation, Neural tissue markers, Oncology

Summary

The synucleins are a small, soluble, highly conserved group of neuronal proteins that have been implicated in neurodegenerative diseases and cancer. The synuclein family consists of α-, β-, and γ-synuclein (SNCG). Synuclein γ (SNCG) is a human gene localized at 10q23.20 23.3. SNCG cDNA is ~5 kb in length and comprised of five exons that translate into a protein of 127 amino acids. In cooperation with other members of the family γ-synuclein plays role in regulation of dopaminergic neurotransmission. Changes of γ-synuclein expression in peripheral tissues has been linked with metabolic and oncological diseases. The α- and β-synuclein proteins participate in the development and function of the central nervous system, and may be important in the etiology and pathogenesis of neurodegenerative disorders such as Alzheimer’s and Parkinson’s di­seases. SNCG is not clearly involved in neurodegenerative diseases. However, a stage-specific upregulation of SNCG has been found in advanced breast carcinomas and other malignancies, including ovarian, gastric, esophagus, liver, colon, pancreatic, and bladder cancers. γ-Synuclein is highly expressed in human white adipose tissue and increased in obesity.

References to Product

References

  • Soukup V, Kalousova M, Capoun O, Sobotka R, Breyl Z, Pesl M, Zima T, Hanus T. Panel of Urinary Diagnostic Markers for Non-Invasive Detection of Primary and Recurrent Urothelial Urinary Bladder Carcinoma. Urol Int. 2015;95 (1):56-64
References to Summary

References to Synuclein-gamma

  • Chen J, Jiao L, Xu C, Yu Y, Zhang Z, Chang Z, Deng Z, Sun Y. Neural protein gamma-synuclein interacting with androgen receptor promotes human prostate cancer progression. BMC Cancer. 2012;12:593
  • Kokhan VS, Van'kin GI, Bachurin SO, Shamakina IY. Differential involvement of the gamma-synuclein in cognitive abilities on the model of knockout mice. BMC Neurosci. 2013;14:53
  • Liang B, Wang XJ, Shen PH, Li XY, Cheng HW, Shan Q, Guo KY, Cao YW, Fan QX, Zheng RF, Li B, Zhang W, Li YW, Yang K. Synuclein-gamma suppression mediated by RNA interference inhibits the clonogenicity and invasiveness of MCF-7 cells. Oncol Lett. 2013 Apr;5 (4):1347-1352
  • Millership S, Ninkina N, Guschina IA, Norton J, Brambilla R, Oort PJ, Adams SH, Dennis RJ, Voshol PJ, Rochford JJ, Buchman VL. Increased lipolysis and altered lipid homeostasis protect gamma-synuclein-null mutant mice from diet-induced obesity. Proc Natl Acad Sci U S A. 2012 Dec 18;109 (51):20943-8
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