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Distributed product

thrombomiR™ kit

  • Regulatory status:RUO
  • Type:qPCR diagnostic test
  • Species:Human
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Cat. No. Size Price


New KT-021-TR96 Analysis of 48 samples
New KT-021-TR384 Analysis of 48 samples
PubMed Product Details
Technical Data

Type

qPCR diagnostic test

Description

The thrombomiR™ kit enables simple and standardized analysis of microRNA biomarkers for platelet function.

The kit contains 10 individual platelet function-related biomarkers for

  • monitoring of the drug effects on platelet function, reactivity and haemostasis
  • diagnosis of platelet-related disorders

The kit has the following unique features

  • Works with frozen sample material (serum or plasma)
  • Responds to all platelet-activating signals (ADP, Collagen, etc.)
  • Measures a platelet-signal generated in-vivo thus complementing results from ex vivo platelet-function tests (LTAs, VASP, …)

All-In-One kit: the thrombomiR™ kit contains all necessary reagents for RNA extraction, cDNA synthesis, preparation of PCR Mix, real time PCR analysis, data analysis: tailored software.

Applications

Serum, Plasma

Sample Requirements

200 µl

Summary

Features

Low sample volume:
200 µL human plasma/serum

Platelet function analysis based on the thrombomiR™ signature:
10 thrombomiRs™ and
6 controls/sample

Reduced hands-on time:
primer coated 96 (Cat. No: KT-021-TR96) or 384 (Cat. No: KT-021-TR384) well plates

High throughput:
one kit allows analysis of up to 48 samples
(6 samples/plate, 8 plates/kit)

Fast and simple data analysis:
thrombomiR™ software included

Summary References (8)

References to platelet function - related miRNA

  • Bye A, et al. Circulating microRNAs predict future fatal myocardial infarction in healthy individuals - The HUNT study. 2016 J Mol Cell Cardiol.
  • Kaudewitz D, et al. Association of MicroRNAs and YRNAs With Platelet Function. 2016 Circ Res.
  • Mayr M, et al. MicroRNAs within the continuum of postgenomics biomarker discovery. 2013 Arterioscler Thromb Vasc Biol.
  • Willeit P, et al. Circulating microRNAs as novel biomarkers for platelet activation. 2013 Circ Res.
  • Willeit P, et al. Circulating MicroRNA-122 Is Associated With The Risk of New-Onset Metabolic Syndrome And Type-2-Diabetes. 2016 Diabetes.
  • Zampetaki A, et al. Prospective study on circulating MicroRNAs and risk of myocardial infarction. 2012 J Am Coll Cardiol.
  • Zampetaki A, et al. Plasma microRNA profling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. 2010 Circ Res.
  • Sunderland N, et al. MicroRNA Biomarkers and Platelet Reactivity: The Clot Thickens. 2017 Circ. Res.
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