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Manufactured by BioVendor

TSG Human E. coli

  • Regulatory status:RUO
  • Type:Recombinant protein
  • Source:E. coli
  • Other names:Twisted Gastrulation Protein
  • Species:Human
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Cat. No. Size Price

RBG10333010 10 µg
RBG10333050 50 µg
RBG10333100 100 μg
PubMed Product Details
Technical Data


Recombinant protein


Twisted Gastrulation Protein (TSG) is a secreted BMP-binding protein that is structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins, and can act either as a BMP-4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP-4/Chordin complex. Recombinant Human TSG is a 198 amino acid, 22.2 kDa protein containing the BMP/TGF-β binding portion of the full length TSG protein.

Amino Acid Sequence



E. coli



Biological Activity

Determined by its ability to neutralize BMP-6 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is 2.0 µg/ml of TSG.


Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).


Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1–1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at –20°C to –80°C.




Research topic

Bone and cartilage metabolism

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