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Cartilage Oligomeric Matrix Protein (COMP, Thrombospondin-5, TSP5)

Cartilage oligomeric matrix protein (COMP), also designated thrombospondin 5 (TSP 5), is non-collagenous glycoprotein and is a member of the thrombospondin family of extracellular proteins. COMP is a calcium-binding protein of high molecular weight (>500kDa) present in the extracellular matrix of articular, nasal and tracheal cartilage. COMP is not only cartilage-derived but was found widely in other tissues, including synovium and tendon. Intact COMP is pentameric, with five identical subunits and the carboxy-terminal globular domain of native COMP binds to collagens I, II, and IX. It has been proposed that COMP molecules are important for maintaining the properties and integrity of collagen network. In addition COMP may have a storage and delivery function for hydrophobic cellsignaling molecules such as vitamin D. The significance of COMP for normal development and function of cartilage has been underscored by the discovery that mutations of the COMP gene result in pseudoachondro­plasia and some forms of multiple epiphyseal dysplasia. Most published studies have shown that serum levels of COMP provide important information about metabolic changes occurring in the cartilage matrix in joint disease. These studies describe that serum COMP level correlated with cartilage degradation and is a potential prognostic marker in inflammatory joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). Results have demonstrated an association of increasing serum COMP levels with progressive destruction of articular cartilage monitored radiographically. OA and RA are a common disease causing pain and disability in a significant proportion of the adult population and early diagnostics of these diseases is very important for future therapy.

1 result found in Immunoassays
1 result found in Proteins
3 results found in Antibodies

Immunoassays
Product Size Price
Cartilage Oligomeric Matrix Protein Human ELISA

Type: Sandwich ELISA, Biotin-labelled antibody

RD194080200 96 wells (1 kit)
 
Proteins
Product Size Price
Cartilage Oligomeric Matrix Protein Human HEK293

Type: Recombinant

RD172080100 0.1 mg
 
Antibodies
Product Size Price
Cartilage Oligomeric Matrix Protein Human, Mouse Monoclonal Antibody, Clone: 12C4

Type: Monoclonal Antibody

RD182080100C4 0.1 mg
 
Cartilage Oligomeric Matrix Protein Human, Mouse Monoclonal Antibody, Clone: 16F12

Type: Monoclonal Antibody

RD182080100F1 0.1 mg
 
Cartilage Oligomeric Matrix Protein Human, Mouse Monoclonal Antibody, Clone: 17C10

Type: Monoclonal Antibody

RD182080100C1 0.1 mg