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Manufactured by BioVendor

Chemerin Human ELISA

  • Regulatory status:RUO
  • Type:Sandwich ELISA, Biotin-labelled antibody
  • Other names:Tezarotene induced gene 2, TIG2, Retinoic acid receptor responder 2, RERRES2
  • Species:Human
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Cat. No. Size Price


RD191136200R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Sandwich ELISA, Biotin-labelled antibody

Applications

Serum, Plasma

Sample Requirements

5 μl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Curve

Calibration Range

0.25–8 ng/ml

Limit of Detection

0.1 ng/ml

Intra-assay (Within-Run)

n = 8; CV = 6.0%

Inter-assay (Run-to-Run)

n = 6; CV = 7.6%

Spiking Recovery

96,40%

Dilution Linearity

103,20%

Crossreactivity

  • bovine Non-detectable
  • cat Not tested
  • dog Non-detectable
  • goat Non-detectable
  • hamster Non-detectable
  • horse Non-detectable
  • monkey Non-detectable
  • mouse Non-detectable
  • pig Non-detectable
  • rat Non-detectable
  • sheep Non-detectable
  • chicken Not tested
  • human Yes
  • rabbit None-specific binding
Summary

Features

  • It is intended for research use only.
  • The total assay time is less than 3.5 hours.
  • The kit measures chemerin in serum and plasma (EDTA, citrate, heparin).
  • Assay format is 96 wells.
  • Standard is recombinant protein based
  • Quality Controls are human serum based. No animal sera are used.
  • Components of the kit are provided ready to use, concentrated or lyophilized.

Research topic

Energy metabolism and body weight regulation

Product References (44)

References

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  • Chakaroun R, Raschpichler M, Klöting N, Oberbach A, Flehmig G, Kern M, SchönMR, Shang E, Lohmann T, Dreßler M, Fasshauer M, Stumvoll M, Blüher M. Effects of weight loss and exercise on chemerin serum concentrations and adipose tissueexpression in human obesity. Metabolism. 2012 May;61(5):706-14. doi:10.1016/j.metabol.2011.10.008. Epub 2011 Dec 2. PubMed PMID: 22136911. See more on PubMed
  • Chamberland JP, Berman RL, Aronis KN, Mantzoros CS. Chemerin is expressedmainly in pancreas and liver, is regulated by energy deprivation, and lacksday/night variation in humans. Eur J Endocrinol. 2013 Sep 13;169(4):453-62. doi: 10.1530/EJE-13-0098. Print 2013 Oct. PubMed PMID: 23904282; PubMed Central PMCID:PMC3798003. See more on PubMed
  • Coimbra S, Brandão Proença J, Santos-Silva A, Neuparth MJ. Adiponectin,leptin, and chemerin in elderly patients with type 2 diabetes mellitus: a closelinkage with obesity and length of the disease. Biomed Res Int. 2014;2014:701915.doi: 10.1155/2014/701915. Epub 2014 Jul 2. PubMed PMID: 25105135; PubMed Central PMCID: PMC4101968. See more on PubMed
  • Derosa G, Cicero AF, Carbone A, Querci F, Fogari E, D'Angelo A, Maffioli P.Results from a 12 months, randomized, clinical trial comparing anolmesartan/amlodipine single pill combination to olmesartan and amlodipinemonotherapies on blood pressure and inflammation. Eur J Pharm Sci. 2014 Jan23;51:26-33. doi: 10.1016/j.ejps.2013.08.031. Epub 2013 Aug 30. Retraction in:Eur J Pharm Sci. 2018 Oct 15;123:584. PubMed PMID: 23999037. See more on PubMed
  • Eisinger K, Bauer S, Schäffler A, Walter R, Neumann E, Buechler C,Müller-Ladner U, Frommer KW. Chemerin induces CCL2 and TLR4 in synovialfibroblasts of patients with rheumatoid arthritis and osteoarthritis. Exp MolPathol. 2012 Feb;92(1):90-6. doi: 10.1016/j.yexmp.2011.10.006. Epub 2011 Oct 19. PubMed PMID: 22037282. See more on PubMed
  • El-Mesallamy HO, El-Derany MO, Hamdy NM. Serum omentin-1 and chemerin levelsare interrelated in patients with Type 2 diabetes mellitus with or withoutischaemic heart disease. Diabet Med. 2011 Oct;28(10):1194-200. doi:10.1111/j.1464-5491.2011.03353.x. Erratum in: Diabet Med. 2012 Jan;29(1):158.PubMed PMID: 21668495. See more on PubMed
  • Engin-Üstün Y, Çağlayan EK, Göçmen AY, Polat MF. Postmenopausal OsteoporosisIs Associated with Serum Chemerin and Irisin but Not with Apolipoprotein MLevels. J Menopausal Med. 2016 Aug;22(2):76-9. doi: 10.6118/jmm.2016.22.2.76.Epub 2016 Aug 30. PubMed PMID: 27617241; PubMed Central PMCID: PMC5016507. See more on PubMed
  • Flehmig G, Scholz M, Klöting N, Fasshauer M, Tönjes A, Stumvoll M, Youn BS,Blüher M. Identification of adipokine clusters related to parameters of fat mass,insulin sensitivity and inflammation. PLoS One. 2014 Jun 26;9(6):e99785. doi:10.1371/journal.pone.0099785. eCollection 2014. PubMed PMID: 24968098; PubMedCentral PMCID: PMC4072672. See more on PubMed
  • Ghallab NA, Shaker OG. Serum and salivary levels of chemerin and MMP-9 in oralsquamous cell carcinoma and oral premalignant lesions. Clin Oral Investig. 2017Apr;21(3):937-947. doi: 10.1007/s00784-016-1846-8. Epub 2016 May 10. PubMed PMID:27161218. See more on PubMed
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  • Hernández EÁ, Kahl S, Seelig A, Begovatz P, Irmler M, Kupriyanova Y, NowotnyB, Nowotny P, Herder C, Barosa C, Carvalho F, Rozman J, Neschen S, Jones JG,Beckers J, de Angelis MH, Roden M. Acute dietary fat intake initiates alterationsin energy metabolism and insulin resistance. J Clin Invest. 2017 Feb1;127(2):695-708. doi: 10.1172/JCI89444. Epub 2017 Jan 23. PubMed PMID: 28112681;PubMed Central PMCID: PMC5272194. See more on PubMed
  • Horn P, von Loeffelholz C, Forkert F, Stengel S, Reuken P, Aschenbach R,Stallmach A, Bruns T. Low circulating chemerin levels correlate with hepaticdysfunction and increased mortality in decompensated liver cirrhosis. Sci Rep.2018 Jun 18;8(1):9242. doi: 10.1038/s41598-018-27543-6. PubMed PMID: 29915268;PubMed Central PMCID: PMC6006249. See more on PubMed
  • Imai K, Takai K, Hanai T, Shiraki M, Suzuki Y, Hayashi H, Naiki T, NishigakiY, Tomita E, Shimizu M, Moriwaki H. Impact of serum chemerin levels on liverfunctional reserves and platelet counts in patients with hepatocellularcarcinoma. Int J Mol Sci. 2014 Jun 25;15(7):11294-306. doi:10.3390/ijms150711294. PubMed PMID: 24968270; PubMed Central PMCID: PMC4139783. See more on PubMed
  • Kammerer A, Staab H, Herberg M, Kerner C, Klöting N, Aust G. Increasedcirculating chemerin in patients with advanced carotid stenosis. BMC CardiovascDisord. 2018 Apr 13;18(1):65. doi: 10.1186/s12872-018-0803-7. PubMed PMID:29653511; PubMed Central PMCID: PMC5899364. See more on PubMed
  • Klöting N, Fasshauer M, Dietrich A, Kovacs P, Schön MR, Kern M, Stumvoll M,Blüher M. Insulin-sensitive obesity. Am J Physiol Endocrinol Metab. 2010Sep;299(3):E506-15. doi: 10.1152/ajpendo.00586.2009. Epub 2010 Jun 22. PubMedPMID: 20570822. See more on PubMed
  • Luque-Ramírez M, Martínez-García MÁ, Montes-Nieto R, Fernández-Durán E,Insenser M, Alpañés M, Escobar-Morreale HF. Sexual dimorphism in adipose tissuefunction as evidenced by circulating adipokine concentrations in the fastingstate and after an oral glucose challenge. Hum Reprod. 2013 Jul;28(7):1908-18.doi: 10.1093/humrep/det097. Epub 2013 Apr 4. PubMed PMID: 23559188. See more on PubMed
  • Menzel J, Biemann R, Aleksandrova K, Schulze MB, Boeing H, Isermann B, WeikertC. The cross-sectional association between chemerin and bone health in peri/preand postmenopausal women: results from the EPIC-Potsdam study. Menopause. 2018May;25(5):574-578. doi: 10.1097/GME.0000000000001041. PubMed PMID: 29206770;PubMed Central PMCID: PMC5908253. See more on PubMed
  • Meric M, Soylu K, Avci B, Yuksel S, Gulel O, Yenercag M, Coksevim M, Uzun A.Evaluation of plasma chemerin levels in patients with non-dipper blood pressurepatterns. Med Sci Monit. 2014 Apr 28;20:698-705. doi: 10.12659/MSM.890784. PubMedPMID: 24769499; PubMed Central PMCID: PMC4010600. See more on PubMed
  • Neuparth MJ, Proença JB, Santos-Silva A, Coimbra S. Adipokines, oxidizedlow-density lipoprotein, and C-reactive protein levels in lean, overweight, andobese portuguese patients with type 2 diabetes. ISRN Obes. 2013 Jan17;2013:142097. doi: 10.1155/2013/142097. eCollection 2013. PubMed PMID:24634792; PubMed Central PMCID: PMC3901968. See more on PubMed
  • Oluwagbemigun K, Buyken AE, Alexy U, Schmid M, Herder C, Nöthlings U.Developmental trajectories of body mass index from childhood into lateadolescence and subsequent late adolescence-young adulthood cardiometabolic risk markers. Cardiovasc Diabetol. 2019 Jan 19;18(1):9. doi:10.1186/s12933-019-0813-5. PubMed PMID: 30660185; PubMed Central PMCID:PMC6339359. See more on PubMed
  • Ouwens DM, Bekaert M, Lapauw B, Van Nieuwenhove Y, Lehr S, Hartwig S, Calders P, Kaufman JM, Sell H, Eckel J, Ruige JB. Chemerin as biomarker for insulinsensitivity in males without typical characteristics of metabolic syndrome. Arch Physiol Biochem. 2012 Jul;118(3):135-8. doi: 10.3109/13813455.2012.654800. Epub2012 Feb 15. PubMed PMID: 22335466. See more on PubMed
  • Pfau D, Bachmann A, Lössner U, Kratzsch J, Blüher M, Stumvoll M, Fasshauer M. Serum levels of the adipokine chemerin in relation to renal function. DiabetesCare. 2010 Jan;33(1):171-3. doi: 10.2337/dc09-1351. Epub 2009 Oct 16. PubMedPMID: 19837789; PubMed Central PMCID: PMC2797967. See more on PubMed
  • Pfau D, Stepan H, Kratzsch J, Verlohren M, Verlohren HJ, Drynda K, Lössner U, Blüher M, Stumvoll M, Fasshauer M. Circulating levels of the adipokine chemerinin gestational diabetes mellitus. Horm Res Paediatr. 2010;74(1):56-61. doi:10.1159/000282114. Epub 2010 Apr 29. PubMed PMID: 20424419. See more on PubMed
  • Polyzos SA, Kountouras J, Anastasilakis AD, Geladari EV, Mantzoros CS. Irisin in patients with nonalcoholic fatty liver disease. Metabolism. 2014Feb;63(2):207-17. doi: 10.1016/j.metabol.2013.09.013. Epub 2013 Oct 18. PubMedPMID: 24140091. See more on PubMed
  • Ress C, Tschoner A, Engl J, Klaus A, Tilg H, Ebenbichler CF, Patsch JR, Kaser S. Effect of bariatric surgery on circulating chemerin levels. Eur J Clin Invest.2010 Mar;40(3):277-80. doi: 10.1111/j.1365-2362.2010.02255.x. Epub 2010 Jan 25.PubMed PMID: 20105226. See more on PubMed
  • Reverchon M, Cornuau M, Ramé C, Guerif F, Royère D, Dupont J. Chemerininhibits IGF-1-induced progesterone and estradiol secretion in human granulosacells. Hum Reprod. 2012 Jun;27(6):1790-800. doi: 10.1093/humrep/des089. Epub 2012Mar 23. PubMed PMID: 22447628. See more on PubMed
  • Saremi A, Asghari M, Ghorbani A. Effects of aerobic training on serumomentin-1 and cardiometabolic risk factors in overweight and obese men. J Sports Sci. 2010 Jul;28(9):993-8. doi: 10.1080/02640414.2010.484070. PubMed PMID:20544489. See more on PubMed
  • Saremi A, Shavandi N, Parastesh M, Daneshmand H. Twelve-week aerobic training decreases chemerin level and improves cardiometabolic risk factors in overweight and obese men. Asian J Sports Med. 2010 Sep;1(3):151-8. PubMed PMID: 22375203;PubMed Central PMCID: PMC3289180. See more on PubMed
  • Sell H, Divoux A, Poitou C, Basdevant A, Bouillot JL, Bedossa P, Tordjman J,Eckel J, Clément K. Chemerin correlates with markers for fatty liver in morbidly obese patients and strongly decreases after weight loss induced by bariatricsurgery. J Clin Endocrinol Metab. 2010 Jun;95(6):2892-6. doi:10.1210/jc.2009-2374. Epub 2010 Apr 7. PubMed PMID: 20375212. See more on PubMed
  • Sell H, Laurencikiene J, Taube A, Eckardt K, Cramer A, Horrighs A, Arner P,Eckel J. Chemerin is a novel adipocyte-derived factor inducing insulin resistancein primary human skeletal muscle cells. Diabetes. 2009 Dec;58(12):2731-40. doi:10.2337/db09-0277. Epub 2009 Aug 31. PubMed PMID: 19720798; PubMed Central PMCID:PMC2780878. See more on PubMed
  • Stejskal D, Karpisek M, Hanulova Z, Svestak M. Chemerin is an independentmarker of the metabolic syndrome in a Caucasian population--a pilot study. BiomedPap Med Fac Univ Palacky Olomouc Czech Repub. 2008 Dec;152(2):217-21. PubMedPMID: 19219210. See more on PubMed
  • Stepan H, Philipp A, Roth I, Kralisch S, Jank A, Schaarschmidt W, Lössner U,Kratzsch J, Blüher M, Stumvoll M, Fasshauer M. Serum levels of the adipokinechemerin are increased in preeclampsia during and 6 months after pregnancy. RegulPept. 2011 Jun 7;168(1-3):69-72. doi: 10.1016/j.regpep.2011.03.005. Epub 2011 Apr12. PubMed PMID: 21477622. See more on PubMed
  • Tönjes A, Fasshauer M, Kratzsch J, Stumvoll M, Blüher M. Adipokine pattern in subjects with impaired fasting glucose and impaired glucose tolerance incomparison to normal glucose tolerance and diabetes. PLoS One. 2010 Nov9;5(11):e13911. doi: 10.1371/journal.pone.0013911. PubMed PMID: 21085476; PubMed Central PMCID: PMC2976690. See more on PubMed
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  • Yilmaz Y, Kurt R, Gurdal A, Alahdab YO, Yonal O, Senates E, Polat N, Eren F,Imeryuz N, Oflaz H. Circulating vaspin levels and epicardial adipose tissuethickness are associated with impaired coronary flow reserve in patients withnonalcoholic fatty liver disease. Atherosclerosis. 2011 Jul;217(1):125-9. doi:10.1016/j.atherosclerosis.2011.03.026. Epub 2011 Mar 29. PubMed PMID: 21513939. See more on PubMed
  • Yilmaz Y, Yonal O, Kurt R, Alahdab YO, Eren F, Ozdogan O, Celikel CA, Imeryuz N, Kalayci C, Avsar E. Serum levels of omentin, chemerin and adipsin in patients with biopsy-proven nonalcoholic fatty liver disease. Scand J Gastroenterol. 2011 Jan;46(1):91-7. doi: 10.3109/00365521.2010.516452. Epub 2010 Sep 1. PubMed PMID: 20809771. See more on PubMed
  • Menzel J, di Giuseppe R, Biemann R, Wittenbecher C, Aleksandrova K, EichelmannF, Fritsche A, Schulze MB, Boeing H, Isermann B, Weikert C. Association betweenchemerin, omentin-1 and risk of heart failure in the population-basedEPIC-Potsdam study. Sci Rep. 2017 Oct 26;7(1):14171. doi:10.1038/s41598-017-14518-2. PubMed PMID: 29075000; PubMed Central PMCID:PMC5658383. See more on PubMed
  • Polyzos SA, Kountouras J, Anastasilakis AD, Triantafyllou GΑ, Mantzoros CS.Activin A and follistatin in patients with nonalcoholic fatty liver disease.Metabolism. 2016 Oct;65(10):1550-8. doi: 10.1016/j.metabol.2016.07.009. Epub 2016Jul 25. PubMed PMID: 27621190; PubMed Central PMCID: PMC5022788. See more on PubMed
  • Becer E, Çırakoğlu A. Effect of the Pro12Ala Polymorphism of the PeroxisomeProliferator-activated Receptor γ2 Gene on Lipid Profile and Adipokines Levels inObese Subjects. Balkan J Med Genet. 2017 Jun 30;20(1):71-80. doi:10.1515/bjmg-2017-0007. eCollection 2017 Jun 30. PubMed PMID: 28924543; PubMedCentral PMCID: PMC5596824. See more on PubMed
  • Hartl A, Sieper J, Syrbe U, Listing J, Hermann KG, Rudwaleit M, Poddubnyy D.Serum levels of leptin and high molecular weight adiponectin are inverselyassociated with radiographic spinal progression in patients with ankylosingspondylitis: results from the ENRADAS trial. Arthritis Res Ther. 2017 Jun15;19(1):140. doi: 10.1186/s13075-017-1350-9. PubMed PMID: 28619118; PubMedCentral PMCID: PMC5471667. See more on PubMed
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  • Eichelmann F, Weikert C, di Giuseppe R, Biemann R, Isermann B, Schulze MB,Boeing H, Aleksandrova K. Methodological utility of chemerin as a novel biomarkerof immunity and metabolism. Endocr Connect. 2017 Jul;6(5):340-347. doi:10.1530/EC-17-0098. Epub 2017 Jun 7. PubMed PMID: 28592510; PubMed Central PMCID:PMC5510453. See more on PubMed
Summary References (7)

References to Chemerin

  • Bozaoglu K, Bolton K, McMillan J, Zimmet P, Jowett J, Collier G, Walder K, Segal D. Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology. 2007 Oct;148 (10):4687-94
  • Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, Muruganandan S, Sinal CJ. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem. 2007 Sep 21;282 (38):28175-88
  • MacDougald OA, Burant CF. The rapidly expanding family of adipokines. Cell Metab. 2007 Sep;6 (3):159-61
  • Parolini S, Santoro A, Marcenaro E, Luini W, Massardi L, Facchetti F, Communi D, Parmentier M, Majorana A, Sironi M, Tabellini G, Moretta A, Sozzani S. The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues. Blood. 2007 May 1;109 (9):3625-32
  • Roh SG, Song SH, Choi KC, Katoh K, Wittamer V, Parmentier M, Sasaki S. Chemerin--a new adipokine that modulates adipogenesis via its own receptor. Biochem Biophys Res Commun. 2007 Nov 3;362 (4):1013-8
  • Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, Iida K, Okimura Y, Kaji H, Kitazawa S, Kasuga M, Chihara K. Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes. FEBS Lett. 2008 Mar 5;582 (5):573-8
  • Wittamer V, Franssen JD, Vulcano M, Mirjolet JF, Le Poul E, Migeotte I, Brezillon S, Tyldesley R, Blanpain C, Detheux M, Mantovani A, Sozzani S, Vassart G, Parmentier M, Communi D. Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J Exp Med. 2003 Oct 6;198 (7):977-85
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