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Coagulation Factor VIII (Coagulation factor VIII, Procoagulant component, Antihemophilic factor, AHF, F8, F8C, F8B, HEMA, FVIII, DXS1253E, F8 protein.)

Coagulation factor VIII participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

6 results found in Proteins

Product Size Price
Coagulation Factor VIII, Human Recombinant

Type: Recombinant protein

New RP1723180250 250 IU $1496,25
New RP1723180500 500 IU $2552,55
New RP1723181000 1000 IU $3937,5
Coagulation Factor VIII, Human, Purified Protein

Type: Native protein

Discount RP1723170200 200 IU $534,54
Discount RP1723170400 400 IU $965,18
Discount RP1723170600 600 IU $1291,93