FGF2-STAB is a stabilized growth factor that offers a novel way to grow FGF2-dependent cell cultures more efficiently, with fewer media changes. FGF2-STAB retains full biological activity even after five days at 37°C. The stable level of FGF2 in culture allows for a more homogenous, undifferentiated stem cell culture, while saving researchers valuable time and money, as repeated supplementation by FGF2 and every day medium change is not required. FGF2 is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary gland, kidney, retina, bone, testis, adrenal gland, liver, monocytes, epithelial cells and endothelial cells. FGF2 functions as a pleiotropic regulator of proliferation, differentiation, migration, and survival in a variety of cell types and is an essential component of media for the cultivation of human pluripotent stem cells because it helps maintain the cells in the pluripotent state. This property makes cells valuable for studying embryogenesis, for drug discovery, and for cell-based therapies.
- References to Fibroblast Growth Factor 2 Stable