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Hepatitis B Virus Protein X (HBx)

Hepatitis B virus X protein (HBx) is a 17 kD transcriptional coactivator that plays a significant role in the regulation of genes involved in inflammation and cell survival. It regulates many transcription factors including nuclear factor kappa B (NF-kappaB) and plays a key role in hepatocarcino­genesis. HBx facilitates the binding of cAMP response element binding protein (CREB) to its responsive element. HBx stabilizes the cellular coactivator ASC-2 through direct protein-protein interaction, affecting the regulation of genes actively transcribed in liver cancer cells. HBx transactivates both JNK and MAPK signal transduction pathways in association with the mobilization of cytosolic Ca2+. The communication between HBx and general transcription factor TFIIB is also one of the mechanisms which account for its transcriptional transactivation. HBx decreased the expression of PTEN a known tumor suppressor and a negative regulator of phosphatidyli­nositol 3'-kinase/AKT and HBx decreased the expression of PTEN in HBx-transfected cells. The etiology of hepatocellular carcinoma (HCC) is involved with hepatitis B virus (HBV) infection and HBx in particular plays a role in the development of HBV-related HCC. The persistence of HBx is important to the pathogenesis of early HCC and HBx expression in the liver during chronic HBV infection may be an important prognostic marker for the development of HCC.

3 results found in Proteins
1 result found in Antibodies

Proteins
Product Size Price
Hepatitis B Virus Protein X Hepatitis B virus E. coli

Type: Recombinant protein

New RD972038100-B 0.1 mg
 
Hepatitis B Virus Protein X Hepatitis B virus E. coli Tag free

Type: Recombinant protein

RD972038025 0.025 mg
RD972038100 0.1 mg
 
Antibodies
Product Size Price
Hepatitis B Protein X (HBx) Virus Human, Rabbit Polyclonal Antibody

Type: Polyclonal Antibody

RD981038100 0.05 mg