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Herstatin (V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog, HER-2, ERBB2, hCG_28177)

HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of an alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.

2 results found in Proteins
5 results found in Antibodies

Proteins
Product Size Price
Herstatin Human E. coli Tag free

Type: Recombinant protein

RD172039025 0.025 mg
RD172039100 0.1 mg
 
Antibodies
Product Size Price
Herstatin Human, Mouse Monoclonal Antibody, Clone: 10C7

Type: Monoclonal Antibody

RD182039100C7 0.1 mg
 
Herstatin Human, Mouse Monoclonal Antibody, Clone: 2D4

Type: Monoclonal Antibody

RD1820391002D4 0.1 mg
 
Herstatin Human, Mouse Monoclonal Antibody, Clone: 2E9

Type: Monoclonal Antibody

RD1820391002E9 0.1 mg
 
Herstatin Human, Mouse Monoclonal Antibody, Clone: 7H3

Type: Monoclonal Antibody

RD1820391007H3 0.1 mg
 
Herstatin Human, Rabbit Polyclonal Antibody

Type: Polyclonal Antibody

RD181039050 0.05 mg