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Homoarginine ELISA

  • Regulatory status:RUO
  • Type:Competitive ELISA
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REA205/96R 96 wells (1 kit)
PubMed Product Details
Technical Data

Type

Competitive ELISA

Applications

Serum, Plasma, Cell culture supernatant

Sample Requirements

20 µl/well

Shipping

At ambient temperature. Upon receipt, store the product at the temperature recommended below.

Storage/Expiration

2–8°C

Calibration Range

7 - 0,3 µmol/l 1318 - 56 ng/ml

Limit of Detection

0.05 µmol/l

Intra-assay (Within-Run)

3,3 - 6,2 %

Spiking Recovery

95 - 103 %

Dilutation Linearity

99 - 103 %

Summary

Research topic

Cardiovascular disease

Summary

Homoarginine is a non-essential cationic amino acid, which is formed from lysine. In vitro and in vivo, homoarginine shows characteristics similar to arginine. Epidemiological investigations in two large independent cohorts, namely the German diabetes dialysis (4D) – study and the Ludwigshafen Risk and Cardiovascular Health (LURIC) – study have identified homoarginine as useful predictor of cardiovascular events and mortality. Beyond that homoarginine concentrations are directly correlated with kidney function and are significantly associated with the progression of chronic kidney disease (CKD). Low homoarginine concentrations might be an early indicator of kidney failure and a potential target for the prevention of disease progression which needs further investigations. Furthermore homoarginine could be a useful marker for the monitoring of hemodialysis patients.

Product References (7)

References

  • Drechsler C, Kollerits B, Meinitzer A, März W, Ritz E, König P, Neyer U, Pilz S, Wanner C, Kronenberg F; MMKD Study Group. Homoarginine and progression ofchronic kidney disease: results from the Mild to Moderate Kidney Disease Study.PLoS One. 2013 May 15;8(5):e63560. doi: 10.1371/journal.pone.0063560. Print 2013.PubMed PMID: 23691067; PubMed Central PMCID: PMC3655120. See more on PubMed
  • Choe CU, Atzler D, Wild PS, Carter AM, Böger RH, Ojeda F, Simova O,Stockebrand M, Lackner K, Nabuurs C, Marescau B, Streichert T, Müller C, LüneburgN, De Deyn PP, Benndorf RA, Baldus S, Gerloff C, Blankenberg S, Heerschap A,Grant PJ, Magnus T, Zeller T, Isbrandt D, Schwedhelm E. Homoarginine levels areregulated by L-arginine:glycine amidinotransferase and affect stroke outcome:results from human and murine studies. Circulation. 2013 Sep 24;128(13):1451-61. doi: 10.1161/CIRCULATIONAHA.112.000580. Epub 2013 Sep 4. PubMed PMID: 24004504. See more on PubMed
  • Jaźwińska-Kozuba A, Martens-Lobenhoffer J, Kruszelnicka O, Rycaj J, ChyrchelB, Surdacki A, Bode-Böger SM. Opposite associations of plasma homoarginine andornithine with arginine in healthy children and adolescents. Int J Mol Sci. 2013 Nov 4;14(11):21819-32. doi: 10.3390/ijms141121819. PubMed PMID: 24192823; PubMed Central PMCID: PMC3856037. See more on PubMed
  • Khalil AA, Tsikas D, Akolekar R, Jordan J, Nicolaides KH. Asymmetricdimethylarginine, arginine and homoarginine at 11-13 weeks' gestation andpreeclampsia: a case-control study. J Hum Hypertens. 2013 Jan;27(1):38-43. doi:10.1038/jhh.2011.109. Epub 2011 Dec 8. PubMed PMID: 22158463. See more on PubMed
  • März W, Meinitzer A, Drechsler C, Pilz S, Krane V, Kleber ME, Fischer J,Winkelmann BR, Böhm BO, Ritz E, Wanner C. Homoarginine, cardiovascular risk, and mortality. Circulation. 2010 Sep 7;122(10):967-75. doi:10.1161/CIRCULATIONAHA.109.908988. Epub 2010 Aug 23. PubMed PMID: 20733103. See more on PubMed
  • Ravani P, Maas R, Malberti F, Pecchini P, Mieth M, Quinn R, Tripepi G,Mallamaci F, Zoccali C. Homoarginine and mortality in pre-dialysis chronic kidneydisease (CKD) patients. PLoS One. 2013 Sep 4;8(9):e72694. doi:10.1371/journal.pone.0072694. eCollection 2013. PubMed PMID: 24023762; PubMedCentral PMCID: PMC3762798. See more on PubMed
  • van der Zwan LP, Davids M, Scheffer PG, Dekker JM, Stehouwer CD, Teerlink T.L-Homoarginine and L-arginine are antagonistically related to blood pressure inan elderly population: the Hoorn study. J Hypertens. 2013 Jun;31(6):1114-23. doi:10.1097/HJH.0b013e32836037fb. PubMed PMID: 23552121. See more on PubMed
Summary References (1)

References to Homoarginine

  • Choe CU, Atzler D, Wild PS, Carter AM, Boger RH, Ojeda F, Simova O, Stockebrand M, Lackner K, Nabuurs C, Marescau B, Streichert T, Muller C, Luneburg N, De Deyn PP, Benndorf RA, Baldus S, Gerloff C, Blankenberg S, Heerschap A, Grant PJ, Magnus T, Zeller T, Isbrandt D, Schwedhelm E. Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies. Circulation. 2013 Sep 24;128 (13):1451-61
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