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Distributed product


  • Regulatory status:RUO
  • Type:Sandwich ELISA, HRP-labelled antibody
  • Other names:C-Reactive Protein
  • Species:Human
Cat. No. Size Price

740011 96 wells (1 kit)
PubMed Product Details
Technical Data


Sandwich ELISA, HRP-labelled antibody


Serum, Plasma

Sample Requirements

10 μl/well


At ambient temperature. Upon receipt, store the product at the temperature recommended below.


Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).

Calibration Range

0–10 μg/ml

Limit of Detection

0.02 μg/ml


The kits are CE-IVD certified and intended for professional use.



  • European Union: for in vitro diagnostic use
  • Rest of the world: for research use only!

Research topic

Immune Response, Infection and Inflammation, Sepsis


CRP is an acute-phase protein, produced exclusively in the liver. Serum concentration of CRP increases significantly in cases of both infectious and noninfectious inflammation, of tissue damage and necrosis and in the presence of malignant tumours. CRP is present in the active stages of inflammatory disorders like rheumatoid arthritis, ankylosing spondylitis, Reiter’s syndrome, psoriatic arthropathy, systemic lupus erythematosus, polyarteritis, ulcerative colitis and Crohn’s disease. The CRP level increases dramatically following microbial infections, and this can be particularly helpful for the diagnosis and monitoring of bacterial septicemia in neonates and other immunocompromised patients at risk.

Product References (14)


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  • Hasan A, Akhter N, Al-Roub A, Thomas R, Kochumon S, Wilson A, Koshy M, Al-Ozairi E, Al-Mulla F, Ahmad R. TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation. Int J Mol Sci. 2019 Aug 23;20(17):4112. doi: 10.3390/ijms20174112. PubMed PMID: 31443599. PubMed CentralPMCID: PMC6747275. See more on PubMed
  • Hasan A, Kochumon S, Al-Ozairi E, Tuomilehto J, Ahmad R. Association between Adipose Tissue Interleukin-33 and Immunometabolic Markers in Individuals with Varying Degrees of Glycemia. Dis Markers. 2019 Apr 3;2019:7901062. doi: 10.1155/2019/7901062. eCollection 2019. PubMed PMID: 31073344. PubMed CentralPMCID: PMC6470453. See more on PubMed
  • Khadir A, Kavalakatt S, Dehbi M, Alarouj M, Bennakhi A, Tiss A, Elkum N. DUSP1 Is a Potential Marker of Chronic Inflammation in Arabs with Cardiovascular Diseases. Dis Markers. 2018 Dec 13;2018:9529621. doi: 10.1155/2018/9529621. eCollection 2018. PubMed PMID: 30647800. PubMed CentralPMCID: PMC6311887. See more on PubMed
  • Koelman L, Pivovarova-Ramich O, Pfeiffer AFH, Grune T, Aleksandrova K. Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation. Immun Ageing. 2019 May 21;16:11. doi: 10.1186/s12979-019-0151-1. eCollection 2019. PubMed PMID: 31139232. PubMed CentralPMCID: PMC6530020. See more on PubMed
  • Sikorska D, Orzechowska Z, Rutkowski R, Prymas A, Mrall-Wechta M, Bednarek-Hatlińska D, Roszak M, Surdacka A, Samborski W, Witowski J. Diagnostic value of salivary CRP and IL-6 in patients undergoing anti-TNF-alpha therapy for rheumatic disease. Inflammopharmacology. 2018 Oct;26(5):1183-1188. doi: 10.1007/s10787-018-0515-8. Epub 2018 Jul 24. PubMed PMID: 30043213. PubMed CentralPMCID: PMC6153921. See more on PubMed
  • Haidari F, Hojhabrimanesh A, Helli B, Seyedian SS, Ahmadi-Angali K. Effect of a high-protein diet with β-cryptoxanthin supplementation on metabolic risk factors, oxidative and inflammatory biomarkers in non-alcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled clinical trial. Trials. 2018 Nov 16;19(1):634. doi: 10.1186/s13063-018-3014-8. PubMed PMID: 30445988. PubMed CentralPMCID: PMC6240237. See more on PubMed
  • Khadir A, Kavalakatt S, Madhu D, Hammad M, Devarajan S, Tuomilehto J, Tiss A. Fetuin-A levels are increased in the adipose tissue of diabetic obese humans but not in circulation. Lipids Health Dis. 2018 Dec 22;17(1):291. doi: 10.1186/s12944-018-0919-x. PubMed PMID: 30579336. PubMed CentralPMCID: PMC6303986. See more on PubMed
  • Choi HN, Yim JE. Plasma Adropin as a Potential Marker Predicting Obesity and Obesity-associated Cancer in Korean Patients With Type 2 Diabetes Mellitus. J Cancer Prev. 2018 Dec;23(4):191-196. doi: 10.15430/JCP.2018.23.4.191. Epub 2018 Dec 30. PubMed PMID: 30671402. PubMed CentralPMCID: PMC6330988. See more on PubMed
  • Perdu S, Castellana B, Kim Y, Chan K, DeLuca L, Beristain AG. Maternal obesity drives functional alterations in uterine NK cells. JCI Insight. 2016 Jul 21;1(11):e85560. doi: 10.1172/jci.insight.85560. PubMed PMID: 27699222. PubMed CentralPMCID: PMC5033901. See more on PubMed
  • Gkalpakiotis S, Arenbergerova M, Gkalpakioti P, Potockova J, Arenberger P, Kraml P. Impact of adalimumab treatment on cardiovascular risk biomarkers in psoriasis: Results of a pilot study. J Dermatol. 2017 Apr;44(4):363-369. doi: 10.1111/1346-8138.13661. Epub 2016 Oct 24. PubMed PMID: 27774694. See more on PubMed
  • Eichelmann F, Weikert C, di Giuseppe R, Biemann R, Isermann B, Schulze MB, Boeing H, Aleksandrova K. Methodological utility of chemerin as a novel biomarker of immunity and metabolism. Endocr Connect. 2017 Jul;6(5):340-347. doi: 10.1530/EC-17-0098. Epub 2017 Jun 7. PubMed PMID: 28592510. PubMed CentralPMCID: PMC5510453. See more on PubMed
  • Abu-Farha M, Abubaker J, Al-Khairi I, Cherian P, Noronha F, Kavalakatt S, Khadir A, Behbehani K, Alarouj M, Bennakhi A, Elkum N. Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome. Cardiovasc Diabetol. 2016 Feb 5;15:25. doi: 10.1186/s12933-016-0346-0. PubMed PMID: 26850725. PubMed CentralPMCID: PMC4743238. See more on PubMed
  • Salas-Pérez F, Codner E, Valencia E, Pizarro C, Carrasco E, Pérez-Bravo F. MicroRNAs miR-21a and miR-93 are down regulated in peripheral blood mononuclear cells (PBMCs) from patients with type 1 diabetes. Immunobiology. 2013 May;218(5):733-7. doi: 10.1016/j.imbio.2012.08.276. Epub 2012 Aug 23. PubMed PMID: 22999472. See more on PubMed
Summary References (3)

References to CRP

  • Gewurz H, Mold C, Siegel J, Fiedel B. C-reactive protein and the acute phaseresponse. Adv Intern Med. 1982;27:345-72. Review. PubMed PMID: 7041546. See more on PubMed
  • Johnson HL, Chiou CC, Cho CT. Applications of acute phase reactants ininfectious diseases. J Microbiol Immunol Infect. 1999 Jun;32(2):73-82. Review.PubMed PMID: 11561579. See more on PubMed
  • Powell LJ. C-reactive protein--a review. Am J Med Technol. 1979Feb;45(2):138-42. Review. PubMed PMID: 106726. See more on PubMed
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