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Adiponectin (Adipocyte C1q and collagen domain-containing protein, Adipocyte complement-related 30 kDa protein, ACRP30, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein, ADIPOQ, ACDC, APM1, GBP28 )

Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 aminoacid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells. The protein belongs to the soluble defence collagen superfamily; it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. Together, these complexes make up approximately 0.01% of total serum protein. Adiponectin receptors AdipoR1 and AdipoR2 have been recently cloned; AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. Paradoxically, adipose tissue-expressed adiponectin levels are inversely related to the degree of adiposity. Adiponectin concentrations correlate negatively with glucose, insulin, triglyceride concentrations, liver fat content and body mass index and positively with high-density lipoprotein-cholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal. Adiponectin has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. Of particular interest is that low adiponectin serum levels predict type 2 diabetes independent of other risk factors. Adiponectin also inhibits the inflammatory processes of atherosclerosis suppressing the expression of adhesion and cytokine molecules in vascular endothelial cells and macrophages, respectively. This adipokine plays a role as a scaffold of newly formed collagen in myocardial remodelling after ischaemic injury and also stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signalling in endothelial cells. Low serum adiponectin levels are found in patients with coronary artery disease. Moreover, high circulating levels of adiponectin are associated with decreased risk of myocardial infarction, independent of other factors. Altogether, adiponectin has the potential to become a clinically relevant parameter to be measured routinely in subjects at risk for type 2 diabetes, atherosclerosis and the metabolic syndrome.

8 results found in Immunoassays
12 results found in Proteins.
9 results found in Antibodies.
1 results found in Planar Arrays.

Product: Size:

Adiponectin Human ELISA (Competitive)

Type: Competitive ELISA, Immobilized antigen

RD195023100 96 wells (1 kit)

Adiponectin Human ELISA, High Sensitivity (Sandwich)

Type: Sandwich ELISA, HRP-labelled antibody

RD191023100 96 wells (1 kit)

Adiponectin HMW Human ELISA

Type: Sandwich ELISA, Biotin-labelled antibody

RSCHHMWADN096R 96 wells (1 kit)

Adiponectin Human PENTASET

Type: ELISA development kit

RD120023 1-for 5x 96-well plates

Adiponectin Mouse ELISA

Type: Sandwich ELISA, Biotin-labelled antibody

RD293023100R 96 wells (1 kit)

Adiponectin HMW Mouse/Rat ELISA

Type: Sandwich ELISA, HRP-labelled antibody

RSHAKMAN011R 96 wells (1 kit)

Adiponectin Porcine ELISA

Type: Sandwich ELISA, Biotin-labelled antibody

RD591023200R 96 wells (1 kit)

Adiponectin Mouse PENTASET

Type: ELISA development kit

RD220023 1-for 5x 96-well plates

Product: Size:

Adiponectin Globular Human E. coli

Type: Recombinant

RD172112025 0.025 mg
RD172112100 0.1 mg

Adiponectin Human E. coli

Type: Recombinant

RD172029100 0.1 mg

Adiponectin Human HEK293

Type: Recombinant

RD172023025 0.025 mg
RD172023100 0.1 mg

Adiponectin Human, Trimeric form (HEK)

Type: Recombinant

RD172091100 0.1 mg

Adiponectin HMW-rich Human HEK293, Tag free

Type: Recombinant

RD172023025-C 0.025 mg
RD172023100-C 0.1 mg
RD172023100-C 1mg 1 mg

Adiponectin NATIVE, Human Serum

Type: Native

RD162023050 0.05 mg

Adiponectin Human HEK293 Solution

Type: Recombinant

New: RD172023025-F 0.025 mg
New: RD172023100-F 0.1 mg

Adiponectin Mouse HEK293

Type: Recombinant

RD272023100 0.1 mg

Adiponectin Mouse, Trimeric form HEK

Type: Recombinant

RD272091100 0.1 mg

Adiponectin Porcine HEK293

Type: Recombinant

RD572023100 0.1 mg

Adiponectin Rat HEK293

Type: Recombinant

RD372023100 0.1 mg

Adiponectin Murine Hi-5 Insect cells

Type: Recombinant

RBG20053005 5 µg
RBG20053025 25 µg
RBG20053100 100 μg

Product: Size:

Q-Plex™ Human Adiponectin

RQS462149HU 96 wells (1 kit)
Find more on Adiponectin on pubmed

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