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Insulin is synthesized in the beta-cells of the islets of Langerhans as a precursor molecule, proinsulin. In the secretory granules of the beta-cells, proinsulin is cleaved into insulin and into a 31-amino-acid peptide, called the Connecting Peptide or C-Peptide. Insulin and C-Peptide are secreted in equimolar amounts. However, because of its longer half-life, the plasma concentration of C-peptide is higher than that of insulin. The determination of plasma C-Peptide allows an assessment of the endogenous insulin production, even in the presence of exogenous insulin administration or in the presence of circulating anti-insulin antibodies. Moreover, the determination of C-Peptide in urine provides a reliable index of the insulin production when blood sampling is difficult or when an integrated estimation of C-Peptide secretion over a period of several hours is requested.

Clinical applications:

  • Assessment of residual beta-cell function in diabetics under insulin therapy
  • Detection and monitoring of the remission phase of type I diabetes
  • Adjunct in the differential diagnosis between type I (insulin-dependent) and type II (noninsulin-

dependent) diabetes

  • Diagnosis of insulin-induced factitious hypoglycaemia
  • Contribution to the diagnosis of insulinoma (insulin suppression test)
  • Prognostic index of foetal outcome in pregnant diabetic women
  • Evaluation of insulin secretion in liver disease
  • Monitoring of pancreatectomy

3 results found in Immunoassays
1 results found in Planar Arrays.

Product: Size:

C-Peptide Human ELISA

Type: Sandwich ELISA, HRP-labelled antibody

RIS005R 96 wells (1 kit)

C-Peptide (U-type) Mouse ELISA

Type: Sandwich ELISA, Biotin-labelled antibody

RSHAKRCP031R 96 wells (1 kit)

C-Peptide (U-type) Rat ELISA

Type: Sandwich ELISA, Biotin-labelled antibody

RSHAKRCP030R 96 wells (1 kit)

Product: Size:

Q-Plex™ Human C-Peptide

RQS462849HU 96 wells (1 kit)
Find more on C-Peptide on pubmed

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