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Clusterin (Apolipoprotein J, Apo J)

Clusterin is a 75–80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid, but truncated forms targeted to the nucleus have also been identified.

The precursor polypeptide chain is cleaved proteolytically to remove the 22-mer secretory signal peptide and subsequently between residues 227/228 to generate the alpha and beta chains. These are assembled anti-parallel to give a heterodimeric molecule in which the cysteine-rich centers are linked by five disulfide bridges and are flanked by two predicted coiled-coil alpha-helices and three predicted amphipathic alpha-helices. Clusterin is a heavily N-glycosylated protein.

Across a broad range of species clusterin shows 70% to 80% of sequence homology. It is ubiquitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen.

It is able to bind and form complexes with numerous partners such as immunoglobulins, lipids, heparin, bacteria, complement components, paraoxonase, beta amyloid, leptin and others. Clusterin has been ascribed a plethora of functions such as phagocyte recruitment, aggregation induction, complement attack prevention, apoptosis inhibition, membrane remodelling, lipid transport, hormone transport and/or scavenging, matrix metalloproteinase inhibition.

A detailed mechanism of clusterin has not been defined. One tempting hypothesis says that clusterin is an extracellular chaperone protecting cells from stress induced by degraded and misfolded protein precipitates.Clusterin is up- or downregulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.

3 results found in Immunoassays
5 results found in Proteins.
4 results found in Antibodies.

Product: Size:

Clusterin Human ELISA

Type: Sandwich ELISA, Biotin-labelled antibody

RD194034200R 96 wells (1 kit)

Clusterin Rat ELISA

Type: Sandwich ELISA, Biotin-labelled antibody

RD391034200CS 96 wells (1 kit)

Clusterin Canine ELISA

Type: Sandwich ELISA, Biotin-labelled antibody

RD491034200R 96 wells (1 kit)

Product: Size:

Clusterin Human HEK293

Type: Recombinant

RD172034020 0.02 mg
RD172034100 0.1 mg

Clusterin Human NATIVE, Human Plasma

Type: Native

RD172034100-S 0.1 mg

Clusterin Rat E. coli

Type: Recombinant

RD372034100 0.1 mg

Clusterin Canine E. coli

Type: Recombinant

RD472034100 0.1 mg

Clusterin Canine HEK293

Type: Recombinant

RD472034100-HEK 0.1 mg
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