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Prouroguanylin (Guanylate cyclase activator 2B, Guanylate cyclase C-activating peptide 2, Guanylate cyclase C-activating peptide II, GCAP-II, Uroguanylin, UGN, GUCA2B)

Prouroguanylin is a 112-amino-acid prohormone precursor of uroguanylin- mature biologically active 16-amino-acid peptide cleaved from its C-terminus. Guanylin binds to receptor-guanylate cyclases (CG-C) resulting in increased intracellular cGMP levels leading to CFTCR (Cystic Fibrosis Transmembrane Conductance Regulator) activation and subsequent rise in fluid and electrolyte secretion into the lumen. Prouroguanyline knock-out mice showed impaired renal excretion of external NaCl leasing to elevated blood pressure independent of the level of diatary salt intake.

Prouroguanylin is the predominant circulating molecular form found in circulation and in biological fluids.



1 results found in Immunoassays
1 results found in Proteins.


Product: Size:

Prouroguanylin Human ELISA

Type: Sandwich ELISA, Biotin-labelled antibody

RD191069200R 96 wells (1 kit)

Product: Size:

Prouroguanylin Human E. coli

Type: Recombinant

RD172069100 0.1 mg
Find more on Prouroguanylin on pubmed


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