NKG2D ligand 2 acts as a ligand for the NKG2D receptor on the surface of NK cells. Binding of ULBPs ligands to NKG2D induces production of cytokines and chemokines. NKG2D ligand 2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.. It belongs to the MHC class I family. The CMV glycoprotein UL16 interacts with NKG2D ligand 2 resulting in retention of NKG2D ligand 2 in the endoplasmic reticulum and Golgi apparatus so it does not reach the cell surface.