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Osteocrin (Musclin, OSTN)

Osteocrin is a recently identified secreted protein expression of which was only detected in bone, peaking just after birth and decreasing markedly with age. A 1280-bp mRNA encodes osteocrin producing a mature protein of 103 amino acids with a molecular mass of 11.4 kDa. In primary osteoblastic cell cultures osteocrin expression coincided with matrix formation then decreased in very mature cultures. Treatment of cultures with 1,25-dihydroxyvitamin D3 resulted in a rapid dose-dependent down-regulation of osteocrin expression, suggesting direct regulation. Chronic treatment of primary cultures with osteocrin-conditioned media inhibited mineralization and reduced osteocalcin and alkaline phosphatase expression. These results suggest that osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator.

1 result found in Proteins
1 result found in Antibodies

Proteins
Product Size Price
Osteocrin Human E. coli

Type: Recombinant protein

RD172079100 0.1 mg
 
Antibodies
Product Size Price
Osteocrin Human, Rabbit Polyclonal Antibody

Type: Polyclonal Antibody

RD181079100 0.1 mg