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Prostaglandin D Synthase (BTP, Prostaglandin-H2 D-isomerase, Lipocalin-Type Prostaglandin D Synthase, Prostaglandin-H2 D-isomerase, EC=5.3.99.2, Lipocalin-type prostaglandin-D synthase, Glutathione-independent PGD synthetase, Prostaglandin-D2 synthase, PGD2 synthase, PGDS2, PGDS, Beta-trace protein, Cerebrin-28, PTGDS, PDS)

BTP catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/re­laxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. It has been proposed that the urinary and serum levels may provide a sensitive indicator of renal damage in diabetes mellitus and hypertension. Elevated levels in the coronary circulation may also be associated with angina. Changes in charge and molecular weight microheterogeneity, due to modification of the N-linked oligosaccharides, may be associated with neurodegenerative disease and multiple sclerosis. Detected in meningioma but not in other brain tumors and may be considered a specific cell marker for meningioma.

1 result found in Immunoassays
1 result found in Proteins
2 results found in Antibodies

Immunoassays
Product Size Price
Prostaglandin D Synthase (Lipocalin-type) Human ELISA

Type: Sandwich ELISA, HRP-labelled antibody

RD191113100R 96 wells (1 kit)
 
Proteins
Product Size Price
Prostaglandin D Synthase Human E. coli

Type: Recombinant

RD172113100 0.1 mg
 
Antibodies
Product Size Price
Prostaglandin-D Synthase (Lipocalin-Type) Human, Rabbit Polyclonal Antibody

Type: Polyclonal Antibody

RD181113100 0.1 mg
 
Prostaglandin-D Synthase (Lipocalin-Type) Human, Sheep Polyclonal Antibody

Type: Polyclonal Antibody

RD184113100 0.1 mg