Prostaglandins are synthesized by cyclooxygenase enzymes, which initially convert arachidonic acid to Prostaglandin H2. Prostaglandin synthases then converts Prostaglandin H2 to Prostaglandin E2 (PGE2). This prostaglandin is a vasodilator, as well as facilitator of modulation of sleep/wake cycles, and human immunodeficiency virus replication. PGE2 is associated with several disease states including inflammation, arthritis, endometriosis, and a variety of cancers.
- References to Prostaglandin E2