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Protein disulfide-isomerase A3 (58 kDa glucose-regulated protein, 58 kDa microsomal protein, p58, Disulfide isomerase ER-60, Endoplasmic reticulum resident protein 57,)

Protein disulfide-isomerase A3 is localized in endoplasmic reticulum. It catalyzes the rearrangement of disulfide bonds, both intrachain and interchain. It is a subunit of the peptide loading complex (PLC), which is a part of the major histocompatibility complex class I pathway. It plays role in protein folding and antigen processing and presentation.

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